Cap1p, a transcription factor of the basic region leucine zipper family, regulates the oxidative stress response (OSR) in Candida albicans. Alteration of its C-terminal cysteine-rich domain (CRD) results in Cap1p nuclear retention and transcriptional activation. To better understand the function of Cap1p in C. albicans, we used genome-wide location profiling (chromatin immunoprecipitation-on-ch...

Abstract Background The plant microbiome plays a vital role in determining host health and productivity. However, we lack real-world comparative understanding of the factors which shape assembly its diverse biota, crucially relationships between microbiota composition health. Here investigated landscape scale rhizosphere microbial processes oilseed rape (OSR), UK’s third most cultivated crop by...

Knowledge of demographic processes and life history strategies is necessary for the conservation management endangered sea turtle populations, but it difficult to ascertain because limited accessibility marine environments that turtles use during different stages their cycle. In such cases, molecular genetics genomic approaches are useful assess mating systems operational sex ratios (OSR), whic...

The demand for environmental protection and energy utilization transformation has promoted the rapid development of integrated systems (IES). Reliability evaluation is a fundamental element in designing IES as it could instruct planning operation IES. This study proposes novel data-driven reliability improvement method considering three-state model an optimal service restoration (OSR). First, m...

Submit Manuscript | http://medcraveonline.com Abbreviations: MIC: Methyl Isocyanate; UCIL: Union Carbide India Ltd; RDX: Research Development Explosive; HAZOP: Hazard Operability Studies; PHA: Preliminary Hazard Analysis; IHA: Interface Hazard Analysis; O&SHA: Operating and Support Hazard Analysis; QRA: Quantitative Risk Analysis; RA: Risk Analysis; MORT: Management Oversight Risk Tree Analysis...

BACKGROUND This study aims to describe trends in the rate of abdominal aortic aneurysm (AAA) and use of open surgery repair (OSR) and endovascular aneurysm repair (EVAR) in elderly patients with and without type 2 diabetes in Spain, 2003-2012. METHODS We select all patients with a discharge of AAA using national hospital discharge data. Discharges were grouped by diabetes status: type 2 diabe...

It is a challenge to measure sexual selection because both stochastic events (chance) and deterministic factors (selection) generate variation in individuals' reproductive success. Most researchers realize that random events ('noise') make it difficult to detect a relationship between a trait and mating success (i.e. the presence of sexual selection). There is, however, less appreciation of the...

A major difficulty in fast-rate event-related fMRI experiments is the extensive overlap from adjacent trials in the stimulus sequence. One approach to address this problem is to include "no-stim" or "null" events as a trial type. These are randomized as if they were true stimulus events but no stimulus actually occurs. Assuming that no response is elicited by the null events, their time-locked ...

One of the main limitations traditional neural-network-based classifiers is assumption that all query data are well represented within their training set. Unfortunately, in real-life scenarios, this often not case, and unknown class may appear during testing, which drastically weakens robustness algorithms. For type problem, open-set recognition (OSR) proposes a new approach where it assumed wo...

Increased aortic stiffness (AoS) has been recognised as a risk factor in the development of cardiovascular disease. The aim this systematic review and meta-analysis was to assess impact repair on AoS. PubMed, Scopus, Web Science were searched systematically for relevant studies evaluating consequences endovascular open Preferred Reporting Items Systematic Reviews Meta-Analysis Protocols (PRISMA...