Motivation: Network alignment (NA) can be pairwise (PNA) and multiple (MNA). PNA produces aligned node pairs between two networks. MNA produces aligned node clusters between more than two networks. Recently, the focus has shi‰ed from PNA to MNA, because MNA captures conserved regions between more networks than PNA (and MNA is thus considered to be more insightful), though at higher computationa...

Charge transfer (CT) properties are compared between peptide nucleic acid structures with an aminoethylglycine backbone (aeg-PNA) and those with a γ-methylated backbone (γ-PNA). The common aeg-PNA is an achiral molecule with a flexible structure, whereas γ-PNA is a chiral molecule with a significantly more rigid structure than aeg-PNA. Electrochemical measurements show that the CT rate constant...

Elevated blood pressure (BP) is the most common cause of cardiovascular disease. Salt intake has a strong influence on BP, and plasma sodium (pNa) is increased with progressive increases in salt intake. However, the associations with pNa and BP had been reported inconsistently. We evaluated the association between pNa and BP, and estimated the risks of all-cause-mortality according to pNa level...

Incorporation of a guanidine functional group into the PNA backbone facilitates cellular uptake of PNA into mammalian cells with efficiency comparable to that of the TAT transduction domain. The modified PNA recognizes and binds to the complementary DNA strand in accordance with Watson-Crick recognition rules. However, unlike polypyrimidine PNA which binds to DNA in 2:1 stoichiometry, the modif...

The persistence of the North Atlantic Oscillation (NAO) is studied using observations of the threedimensional vorticity budget in the Atlantic sector. Analysis of the relative vorticity tendency equation shows that convergence of eddy vorticity flux in the upper troposphere counteracts the effect of anomalous largescale divergence at the upper level. At low levels, the convergence associated wi...

[1] Ice core-derived accumulation records from Greenland have been proposed as proxies for North Atlantic Oscillation (NAO) reconstruction. In a series of single-site analyses, accumulation records from ice cores drilled in western Greenland were found to exhibit the strongest linear association with NAO. In this paper, we expand on these findings by proposing a spatiotemporal statistical model...

Silicon-on-insulator (SOI) CMOS offers a 20–35% performance gain over bulk CMOS. High-performance microprocessors using SOI CMOS have been commercially available since 1998. As the technology moves to the 0.13m generation, SOI is being used by more companies, and its application is spreading to lower-end microprocessors and SRAMs. In this paper, after giving a short history of SOI in IBM, we de...

Climate influences the dynamics of natural populations by direct effects over habitat quality but also modulating the phenotypic responses of organisms' life-history traits. These responses may be different in males and females, particularly in dimorphic species, due to sex-specific requirements or constraints. Here, in a coastal seabird, the European shag (Phalacrocorax aristotelis), we studie...

Silicon On Insulator (SOI) can leverage a lot of new advantages for circuit designers compared to conventional bulk technology. In particular, the improved S-factor and reduced junction capacitance make it very appealing for next generation low power, high performance DRAM systems. However, the benefits of the SOI technology do not come entirely for free. In this project, we characterized the k...

BACKGROUND Studies suggest that siblings of children with peanut allergy (PNA) have a higher prevalence of PNA than the general population. OBJECTIVES The Canadian Peanut Allergy Registry was used to assess the percentage of siblings of registered index PNA children who were 1) never exposed to peanut or 2) reportedly diagnosed with PNA by a physician without either a history of allergic reac...