BACKGROUND Lung cancers are resistant to conventional chemotherapeutic interventions such as paclitaxel. Notch signaling is crucial in the chemoresistance of lung cancer cells. The Notch inhibitor gamma-secretase inhibitor (GSI) inhibits the Notch signaling pathway. MATERIAL AND METHODS Here, we evaluated how Notch-3 inhibition by GSI can enhance the sensitivity of lung cancer cells to paclitax...

D. Schulz-Ertner, C. Thilmann, M. Wannenmacher, J. Debus Before patient irradiations started in 1997, a radiation unit was built at the heavy ion synchrotron of the GSI and major future directed technical and radiobiological innovations have been implemented. For the first time, tumor conform application of carbon beams was realized by intensity-controlled rasterscanning with pulse-to-pulse ene...

ABSTRACT This study aimed to translate, create a cut-off point, and assess the measurement properties of female genital self-image scale (FGSIS) in Brazilian women. Content, structural, construct validity, internal consistency, test-retest reliability, errors were assessed this online study. FGSIS point classify satisfaction with (GSI) was performed using Partial Credit Model (PCM). In total, 6...

This paper introduces a simple, quantitative assessment tool to follow up the recovery of gait. Today, micro-electro-mechanical systems (MEMS) technology provides with small, simple, low-power consuming and easy to don and doff sensors. In our approach we have selected an accelerometer and introduced a new quantity that characterizes the gait pattern in the frequency domain, we term it Gait Spe...

Drug resistance remains a critical problem in the treatment of patients with multiple myeloma. Recent studies have determined that Notch signaling plays a major role in bone marrow (BM) stroma-mediated protection of myeloma cells from de novo drug-induced apoptosis. Here, we investigated whether pharmacologic inhibition of Notch signaling could affect the viability of myeloma cells and their se...