Abstract Objective Research has demonstrated reaction time variability (RTV) as a potentially sensitive metric for post-concussion assessments. The Brain Gauge Clinical Metrics battery (BG) device uses tactile sensory stimulation to elicit response, increasing accuracy <1 msec versus 30–100 in visually-based (RT) measures. We sought determine if BG RTV could adequately identify individua...

In this paper, two local activity-tuned filtering frameworks are proposed for noise removal and image smoothing, where the local activity measurement is given by the clipped and normalized local variance or standard deviation. The first framework is a modified anisotropic diffusion for noise removal of piece-wise smooth image. The second framework is a local activity-tuned Relative Total Variat...

Background: Managing hypertriglyceridemia in HIV-infected patients often requires multiple pharmacologic strategies. Many protease inhibitors (PIs), one of 6 classes of drugs used to treat HIV, have been associated with hypercholesterolemia and drug interactions. For this study, we examined a dual strategy to manage hypertriglyceridemia in HIVinfected patient taking PIs: 1) switching patients t...

It has been shown that virological protease inhibitor (PI) resistance mutations present at the initiation of saquinavir (SQV) plus ritonavir (RTV) therapy in PI-experienced patients are the strongest predictors of virological response. But most of the current resistance algorithms are adapted for unboosted SQV regimens. We applied a stepwise methodology for the development and validation of a c...

In this study we sought to evaluate narlaprevir (NVR) pharmacokinetics (PK) after a single dose with or without ritonavir (RTV) in cirrhotic versus healthy subjects. NVR at 200 mg was administered to 8 healthy and 8 cirrhotic subjects, and NVR at 100 mg with RTV at 100 mg was administered to 8 healthy and 8 cirrhotic subjects. PK analysis was performed. The geometric mean maximum concentration ...

Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASDs) frequently co-occur. However, due to previous exclusionary diagnostic criteria, little is known about the underlying causes of this covariation. Twin studies assessing ADHD symptoms and autistic-like traits (ALTs) suggest substantial genetic overlap, but have largely failed to take into account the genetic hete...

BACKGROUND Combination antiretroviral (AR) therapy continues to be the mainstay for HIV treatment. However, antiretroviral drug nonadherence can lead to the development of resistance and treatment failure. We have designed nanoparticles (NP) that contain three AR drugs and characterized the size, shape, and surface charge. Additionally, we investigated the in vitro release of the AR drugs from ...