KChIPs coassemble with pore-forming Kv4 a subunits to form a native complex in the brain and heart and regulate the expression and gating properties of Kv4 K1 channels, but the mechanisms underlying these processes are unknown. Here we report a co-crystal structure of the complex of human Kv4.3 N-terminus and KChIP1 at a 3.2-Å resolution. The structure reveals a unique clamping action of the co...

ITE JOURNAL / JANUARY 2001 THE NATIONAL DIALOGUE ON Transportation Operations has identified the need for cultural transitions within transportation organizations from traditional project-driven orientations to approaches focused on continuous systems performance and customer service.1 Institutional change, facilitating interjurisdictional cooperation to provide seamless transportation services...

1School of Public Health and Institute of Public Health Research; 2Isfahan Training and Health Research Centre; 4Bandar Abbas Training and Health Research Centre; 5Yazd Training and Health Research Centre; Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. 3Department of Public Health, Sabzevar University of Medical Sciences, Sabzevar, Islamic Republic of Iran. ABSTRACT An...

The key to success in today’s embedded market is the ability to respond quickly to fluctuations in market demand, last-minute design changes and competitive challenges. Microcontrollers (MCUs) have provided versatile, configurable platforms for embedded systems for many years in this respect, giving developers the flexibility to implement new system features easily and efficiently through firmw...

AbstractIn this work faster unsigned multiplication has been achieved by using a combination of High Performance Multiplication [HPM] column reduction technique and implementing a N-bit multiplier using 4 N/2-bit multipliers (recursive multiplication) and acceleration of the final addition using a hybrid adder. Low power has been achieved by using clock gating technique. Based on the proposed t...

This paper describes an investigation of potential advantages and risks of applying an aggressive asynchronous design methodology to Intel Architecture. RAPPID (“Revolving Asynchronous Pentium® Processor Instruction Decoder”), a prototype IA32 instruction length decoding and steering unit, was implemented using self-timed techniques. RAPPID chip was fabricated on a 0.25μ CMOS process and tested...

Optimization is essential in many scientific and economical areas, but it is often too complex to be tackled by simple straightforward calculations or by trial and error. Two well-known methods to find low-lying minima in such complex systems are simulated annealing and the genetic algorithm. In these methods artificial fluctuations control the probability of the system to overcome a local mini...