امروزه توسعه سیستم‌های کارآمد و اثربخش بهداشت درمان به یکی از نگرانی‌های اصلی دولت‌ها تصمیم‌گیرندگان تبدیل شده است. تأمین به‌موقع دارو کارایی سیستم موجودی توزیع، نقشی حیاتی در زنجیره بیمارستانی دارند برای افزایش این فعالیت‌ها، فرآیند تصمیم‌گیری مناسب مدیریت ضروری نظر می‌رسد. پژوهش یک مدل دوهدفه به‌صورت برنامه‌ریزی خطی عدد صحیح مختلط جریان اطلاعات ارائه اهداف حداقل­کردن هزینه‌های خرید، نگهداری، ...

نخستین گام در راستای تحلیل و ارزیابی ریسک‌های زنجیره تأمین شناسایی این ریسک‌ها است. روش‌های مرسوم بر اساس فیلترهای دستی یا خودکار داده‌­محور ارائه شده فیلتر به‌­دلیل محدودیت‌های نمونه‌گیری دارای مشکلات اعتبارسنجی هستند از طرف دیگر مبتنی داده، داده‌های ریسک که پیچیده مبهم هستند، عملکرد ضعیفی دارند. برای پرکرده خلل پژوهشی، پژوهش، چارچوبی تعاملی بین تحلیل‌­گر ماشین حجم وسیعی حوزه مواد غذایی با است...

The water jet formed after the collapse of bubble in near-field underwater explosion can cause serious damage to local structure ship, and formation is asymmetric, which makes it difficult measure its data experiment. At present, studies on pressure time history curves are still relatively rare. In order study characteristics jet, test 2.5 g TNT explosive at bottom fixed ...

Schwann cell (SC) myelination in the peripheral nervous system is essential for motor function, and uncontrolled SC proliferation occurs in cancer. Here, we show that a dual role for Hippo effectors TAZ and YAP in SC proliferation and myelination through modulating G-protein expression and interacting with SOX10, respectively. Developmentally regulated mutagenesis indicates that TAZ/YAP are cri...

Mastitis is an inflammatory reaction of the mammary tissue in response to the introduction and multiplication of pathogens and is characterized by increasing somatic cell count (SCC) in milk. The main objective of present study is to assess the probable associations between somatic cell (SC) levels and calcium and phosphorus and ratio of Ca/P in raw milk. Milk samples were collected from indivi...

In this work, we experimentally investigate the effect of a grating based pulse stretcher/compressor on the carrier-envelope phase stability of femtosecond pulses. Grating based stretcher-compressor (SC) setups have been avoided in past demonstrations of chirped pulse amplification (CPA) of carrier envelope phase (CEP) stabilized femtosecond pulses, because they were expected to introduce signi...

Hyperexcitable reflex blinks are a cardinal sign of Parkinson's disease. The first step in the circuit linking the basal ganglia and brainstem reflex blink circuits is the inhibitory nigrostriatal pathway (Basso et al., 1996). The current study reports the circuits linking the superior colliculus (SC) to trigeminal reflex blink circuits. Microstimulation of the deep layers of the SC suppresses ...

We used the short-circuit current (I(sc)) technique to investigate the effects of the isoflavone genistein on the electrogenic Cl(-) secretion of the mouse jejunum. Genistein stimulated a sustained increase in I(sc) that was dose dependent. Bumetanide inhibited 76 +/- 5% of the genistein-stimulated I(sc) consistent with activation of Cl(-) secretion. Genistein failed to stimulate I(sc) followin...

OBJECTIVE To establish a stable PrP(Sc) panel from brain tissues of experimental hamsters infected with scrapie agent 263K for evaluating diagnostic techniques of human and animals' prion diseases. METHODS Thirty brain tissue samples from hamsters intracerebrally infected with scrapie strain 263K and another 30 samples from normal hamsters were selected to prepare 10%, 1%, and 0.5% brain homo...

Synthetic cannabinoids (SC), cannabinoid 1 and cannabinoid 2 receptors agonists, are the psychoactive substances. SC was originally produced to treat medical conditions. Compared to other narcotics, SC is easier to obtain, cheap, and highly potent and has a long half-life. In addition, routine analysis does not detect SC, which has led to widespread use. A case is presented that manic episode w...