DUPISTAD (NCT04033367) evaluated the impact of dupilumab on sleep. Adults with moderate-to-severe AD (EASI ≥12, Pruritus numerical rating scale (NRS) ≥ 3 and sleep NRS ≥5) were randomized 2:1 to 300mg every 2 weeks (q2w) or placebo for 12 (W12); both groups permitted concomitant topical corticosteroids. The primary efficacy endpoint was quality percentage change from baseline W12, assessed by 1...

In 2 monotherapy phase 3 studies (ECZTRA 1 and 2) of patients with moderate-to-severe atopic dermatitis (AD) treated tralokinumab, one the primary endpoints was IGA 0/1 (clear/almost clear) at Week 16. However, in a heterogeneous disease like AD, other important clinically meaningful parameters include improvement signs, symptoms, and/or quality life. We assessed impact tralokinumab on AD life ...

M. Breeuwer a, H.L.T. de Bliek a, J. Buurman a, P.A.C. Desmedt a, P. Gieles a, F.A. Gerritsen a, J.P. Wadley b, N.L. Dorward b, B. Velani b, N.D. Kitchen b, D.G.T. Thomas b, O. Wink c, J.D. Blankensteijn c, B.C. Eikelboom c, W.P.Th.M. Mali c, M.A. Viergever c, G.P. Penney d, R. Gaston d, C.R. Maurer d, D.L.G. Hill d, D.J. Hawkes d, J. Weese e, J. Sabczynski e, W. Zylka e, C. Lorenz e, T.M. Buzu...

Under trait theory, ratings may be modeled as a function of the temperament of the child and the bias of the rater. Two linear structural equation models are described, one for mutual self- and partner ratings, and one for multiple ratings of related individuals. Application of the first model to EASI temperament data collected from spouses rating each other shows moderate agreement between rat...

In this paper, we focus on the fourth order cumulant based adaptive methods for independent component analysis. We propose a novel method based on the Jacobi Optimization, available for a wide set of minimum entropy (ME) based contrasts. In this algorithm we adaptively compute a moment matrix, an estimate of some fourth order moments of the whitened inputs. Starting from this matrix, the soluti...

Atopic dermatitis (AD) is one of the most common chronic skin diseases. Treatment options include lubricants, antihistamines, and corticosteroids in either topical or oral forms. Severe AD is frequently recalcitrant to these medications. We reported three cases of severe AD patients who had elevated of IgE levels and failed to response to several prior medical treatment. After being treated wit...