OBJECTIVE Multiple sclerosis (MS) is the most common demyelinating disorder of the central nervous system (CNS). Data suggest that antibodies to CNS targets contribute to the pathogenesis of MS. MS patients produce autoantibodies to heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1). hnRNP A1 is an RNA binding protein (RBP) overexpressed in neurons that functions in pre-mRNA splicing, mRNA t...

Previously (9), I found that immunization of rabbits with antibody directed against variable region heavy chain VH polypeptides of a1 allotype induced the production of antiidiotype (anti-Id) molecules that appeared to bear images of the original a1 allotype. I now show that these anti-Id molecules can be fractionated into two populations: one population (a2a3- anti-Id) that lacks the nominal V...

Cyclin A1 differs from other cyclins in its highly restricted expression pattern. Besides its expression during spermatogenesis, cyclin A1 is also expressed in hematopoietic progenitor cells and in acute myeloid leukemia. We investigated mechanisms that might contribute to cyclin A1 expression in hematopoietic cells. Comparison of cyclin A1 and cyclin A promoter activity in adherent and myeloid...

Let Pn denote the set of all algebraic polynomials of degree at most n with real coefficients. Associated with a set of poles {a1, a2, . . . , an} ⊂ R\ [−1, 1] we define the rational function spaces Pn(a1, a2, . . . , an) := 8< : : f(x) = b0 + n X j=1 bj x− aj , b0, b1, . . . , bn ∈ R 9= ; . Associated with a set of poles {a1, a2, . . . } ⊂ R\[−1, 1] , we define the rational function spaces P(a...

The quest for novel therapeutic targets in acute myeloid leukemia (AML) is still ongoing. One of such targets, cyclin A1, was shown to be overexpressed in AML including AML stem cells. However, the function of cyclin A1 in AML is largely unknown, and the data on its impact on patients' survival remain controversial. Therefore, we developed a transgenic mouse model of stem cell-directed inducibl...

We show that the braided tensor product algebra A1⊗A2 of two module algebras A1,A2 of a quasitriangular Hopf algebraH is equal to the ordinary tensor product algebra of A1 with a subalgebra of A1⊗A2 isomorphic to A2, provided there exists a realization of H within A1. In other words, under this assumption we construct a transformation of generators which ‘decouples’ A1,A2 (i.e. makes them commu...

We measured the period and spin-down rate for SGR 1900+14 during the quiescient period two years before the recent interval of renewed burst activity. We have shown that the spin-down age of SGR 1900+14 is consistent with a braking index of ∼1 which is appropriate for wind torques and not magnetic dipole radiation. We have shown that a combination of dipole radiation, and wind luminosity, coupl...

Dietary protein Fenneropenaeus merguiensis Food Conversion Ratio (FCR) Specific Growth rate (SGR)

We present 1.2 mm continuum images and spectral line observations of CO(1–0) and SiO(3–2) rotational transitions of the recent nova V4743 Sgr. The nova is detected at 1.2 mm showing a variable millimetre emission. Only upper limits of T ⋆ A = 0.06 K for CO and T ⋆ A = 0.03 K for SiO could be derived. We discuss the results in terms the nature of the millimetre emission favouring dust from a pha...