127 Multiple endocrine neoplasia type 2 (MEN2) syndromes are autosomally dominant clinical associations characterised by a number of tumours, including medullary thyroid carcinoma (MTC), phaeochromocytoma, thyroid C-cell hyperplasia (CCH), parathyroid tumours (MEN2A) and ganglioneuroma of the gastrointestinal tract (MEN2B). The common factor in the MEN2 syndromes is MTC, a poorly differentiated...

BACKGROUND Polymerase chain reaction (PCR) assay has widely used for the detection of tuberculosis (TB). This study tried to compare in-house PCR with some well-known commercial PCR kits for detection of TB agent. METHODS Clinical samples obtained from 620 TB suspected patients were analyzed for the diagnosis of Mycobacterium tuberculosis complex (MTC) by in-house PCR. All samples were obtain...

Note Medullary thyroid cancers (MTC) are rare tumors of neuroendocrine origin that arise from parafollicular C cells which secrete a variety of peptides and hormones including calcitonin. As opposed to the more common papillary and follicular thyroid cancer subtypes, MTC represents a rare and under-characterized form of cancer, and can cause death if untreated (Taccaliti et al., 2011). MTC can ...

US-Fine needle aspiration biopsy (US-FNAB) is a simple diagnostic procedure to find malignant thyroid nodules. However, few papers have evaluated the specific value of FNAB to detect medullary thyroid cancer (MTC). This study aimed to appraise the value of FNAB cell blocks in the diagnosis of MTC by a novel cell block preparation method. We retrospectively reviewed four typical cases of MTC tha...

Indirect treatment comparison (ITC) and multiple treatment comparison (MTC) meta-analyses are increasingly being used to estimate the comparative effectiveness of interventions when head-to-head data do not exist. ITC meta-analyses can be conducted using simple methodology to compare two interventions. MTC meta-analyses can be conducted using more complex methodology, often employing Bayesian a...

Introduction: Liver biopsy, which serves as the clinical standard for the detection and surveillance of liver fibrosis and cirrhosis, is an invasive procedure that is prone to sampling error and interobserver variability. Magnetization-transfer contrast (MTC) imaging employs off-resonance radio-frequency pulses to selectively pre-saturate signal from macromolecule-bound protons via chemical exc...

Resins are used in nuclear power plants for water ultrapurification. Two approaches are considered in this work: column experiments and simulations. A software called OPTIPUR was developed, tested and used. The approach simulates the onedimensional reactive transport in porous medium with convectivedispersive transport between particles and diffusive transport within the boundary layer around t...

Mutations in the rei proto-oncogene constitute the germ line defect in patients with inherited forms of medullary thyroid carcinoma (MTC) and are also present in tumor DNA from a subset of patients with sporadic forms of MTC. We now show that the TT cell line of human MTC can be induced within 48 h to resemble mature C cell differentiation by activation of the nil'-1 signal transduction pathway...

Many-Task Computing (MTC) is a widely used computing paradigm for large-scale task-parallel processing. One of the key issues in MTC is to schedule a large number of independent tasks onto heterogeneous resources. Traditional task-level scheduling heuristics, like Min-Min, Sufferage and MaxStd, cannot readily be applied in this scenario. As most of MTC tasks are usually fine-grained, the resour...

BACKGROUND Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations in the rearranged during transfection (RET) proto-oncogene. Not all patients with progressive MTC respond to current therapy inhibiting RET, demanding additional therapeutic strategies. We recently demonstrated that disrupting mitochondrial metabolism using a mitochondria-targeted agent or by deple...