The mechanism whereby fragments of streptokinase (SK) derived from its N terminus (e.g., SK1-59 or SK1-63) enhance the low plasminogen (PG)-activating ability of other fragments, namely SK64-386, SK60-414, SK60-387, and SK60-333 (reported previously), has been investigated using a synthetic peptide approach. The addition of either natural SK1-59, or chemically synthesized SK16-59, at saturation...

The flavin prosthetic group (FAD) of thioredoxin reductase has been replaced by 1-deazaFAD (carbon substituted for nitrogen at position 1). Reduction of 1-deazaFAD-thioredoxin reductase by four electrons proceeds in two stages having midpoint potentials that are separated by 0.063 V. Two-electron reduced 1-deazaFAD-thioredoxin reductase (EH2) has spectral characteristics that are different from...

The human orexin 2 receptor (OX2R) is a G-protein‑coupled receptor (GPCR) that has been implicated in a number of diverse physiological functions. Recent studies have identified a number of functions of the C‑termini of GPCRs. However, the importance of the OX2R C‑terminus in regulating signaling and surface expression remains unclear. In the present study, the function of the OX2R C‑terminus w...

In this paper we examine the status of lexical tones in Sylheti. Sylheti is generally considered to be one of the varieties of Bangla (belonging to the Indo-Aryan language family). The consonant inventory of Sylheti has undergone significant reduction and restructuring, and lost all the aspirated stops due to obstruent weakening ([bai>bai] „brother‟, [lat̪i> lat̪i] „kick‟) and spirantization of t...

(1|1) [1090]. (s, t) [2494]. 1 [299, 421]. 2 [299, 421, 478, 537, 806, 1094, 1134, 1271, 1300, 1373, 1455, 1730, 1797, 1826, 1855, 2023, 2029, 2344]. 3 [251, 299, 314, 691, 768, 1054, 1180, 1197, 1281, 1490, 1601, 1856, 1935, 1979, 2009, 2029, 2344, 2416, 2429, 2435, 2452, 2476, 2517, 2571]. 4 [1639, 1751, 2132]. 5 [299]. 9 [154]. ∗ [1518]. 3 [1482]. RP [669]. A∗ [922]. β [1978]. C [2040]. d [5...

The emergence of human infections with a novel H7N9 influenza strain has raised global concerns about a potential human pandemic. To further understand the character of other influenza viruses of the H7 subtype, we selected two H7N1 avian influenza viruses (AIVs) isolated from wild birds during routine surveillance in China: A/Baer's Pochard/Hunan/414/2010 (BP/HuN/414/10) (H7N1) and A/Common Po...

This thesis presents a low-level implementation of 414-bit multiplication on the ARM Cortex-M0, using four levels of Karatsuba and one level of schoolbook multiplication. This multiplication is an important part of Curve41417 created by D. Bernstein and T. Lange. This implementation requires 4014 clock cycles.