BACKGROUND Cisapride, a gastrointestinal prokinetic agent, was recently withdrawn from the market because of its propensity to induce torsade de pointes (TdP) arrhythmias. The present study examines the electrophysiological actions of cisapride in the isolated arterially perfused canine left ventricular wedge preparation. METHODS AND RESULTS Transmembrane action potentials from epicardial and...

BACKGROUND The aim was to analyse trends in clinically relevant resistance to first-line antiretroviral drugs in Spain, applying the Stanford algorithm, and to compare these results with reported Transmitted Drug Resistance (TDR) defined by the 2009 update of the WHO SDRM list. METHODS We analysed 2781 sequences from ARV naive patients of the CoRIS cohort (Spain) between 2007-2011. Using the ...

OBJECTIVES To evaluate the prevalence of transmitted drug resistance (TDR) and non-B subtypes in patients with acute/recent HIV-1 infection in Barcelona during the period 1997-2012. METHODS Patients from the "Hospital Clínic Primary HIV-1 Infection Cohort" with a genotyping test performed within 180 days of infection were included. The 2009 WHO List of Mutations for Surveillance of Transmitte...

Background—Cisapride, a gastrointestinal prokinetic agent, was recently withdrawn from the market because of its propensity to induce torsade de pointes (TdP) arrhythmias. The present study examines the electrophysiological actions of cisapride in the isolated arterially perfused canine left ventricular wedge preparation. Methods and Results—Transmembrane action potentials from epicardial and M...

INTRODUCTION Earlier antiretroviral therapy (ART) initiation reduces HIV-1 incidence. This benefit may be offset by increased transmitted drug resistance (TDR), which could limit future HIV treatment options. We analyze the epidemiological impact and cost-effectiveness of strategies to reduce TDR. METHODS We develop a deterministic mathematical model representing Kampala, Uganda, to predict t...

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Studies were conducted during August and March–April in the Sargasso Sea south of Bermuda to examine rates of bacterial growth and picoplankton consumption by microbial consumers. Bacterial growth rates were estimated from [3H]thymidine (TdR) incorporation rates, while grazing rates were determined using fluorescently labeled prey (FLP). In addition, net bacterial growth rates were calculated f...

Efficient reconstruction of dispersive dielectric profiles using time domain reflectometry (TDR) P. Leidenberger, B. Oswald, and K. Roth Institute of Environmental Physics, University of Heidelberg, Heidelberg, Germany Received: 29 July 2005 – Accepted: 5 August 2005 – Published: 15 August 2005 Correspondence to: B. Oswald ([email protected]) © 2005 Author(s). This work is l...

OBJECTIVE To assess the emergence of transmitted HIV-1 drug resistance (TDR) in Kampala, Uganda, 10 years after the scale-up of antiretroviral treatment (ART) and to compare with a previous survey among antenatal clinic attendees in 2007 (reporting 0% TDR). DESIGN A cross-sectional survey was conducted among newly HIV-1 diagnosed, antiretroviral-naive young adults attending two large voluntar...

HIV-1-infected individuals with transmitted HIV drug resistance (TDR) begin antiretroviral therapy (ART) with a lower genetic barrier to resistance and a higher risk of both virological failure and of developing further resistance. TDR surveillance informs HIV-1 public health strategies and first line ART. TDR has not been studied nationally in an Irish population. This study includes all new H...