Methods Presence or absence of MVE was noted in patients presenting for routine CMR with MI and non-MI indications requiring LGE. Chi square analysis was performed for non-contiguous variables and SPSS, Chicago software was utilized for statistical analysis. We hypothesize the presence of mitral valve enhancement (MVE) on LGE imaging in post-MI patients is associated with an increased incidence...

AIMS We sought to identify patterns of myocardial fibrosis in vivo in patients with lamin cardiomyopathy, and to determine its functional significance. METHODS AND RESULTS Eleven patients sharing the identical mutation in LMNA without contraindication to magnetic resonance were identified from a 1016-member pedigree. Eight autopsy hearts from deceased relatives were reviewed. Patients and age...

PURPOSE To develop arrhythmia-insensitive inversion recovery sequences for improved visualization of myocardial scar and quantification of diffuse fibrosis. METHODS A novel preparation pre-pulse, called saturation pulse prepared heart-rate-independent inversion recovery, is introduced, which consists of a combination of saturation and inversion pulses to remove the magnetization history in ea...

AIMS The aim of this study was to evaluate the potential of visualizing chronic myocardial infarction in patients using the intravascular CA MS-325 (gadofosveset, EPIX Pharmaceuticals, Mass, USA). METHODS Nine patients were enrolled in a clinical phase II multicenter trial for MRCA and perfusion imaging using MS-325. They had objective evidence of chronic myocardial infarction as visualized b...

Methods We studied 41 patients with persistent AF (6 women, age 56+/-12 years). Patients underwent LGE CMR using an respiratory navigated and inversion recovery prepared 3D turbo FLASH sequence with fat saturation (pixel size 1.25×1.25×2.5mm), as well as non-invasive BSM during atrial fibrillation using a 256-electrode vest, enabling real-time panoramic mapping of atrial electrical activation. ...

Linear Graph Embedding (LGE) is the linearization of graph embedding, which could explain many of the popular dimensionality reduction algorithms such as LDA, LLE and LPP. LGE algorithms have been applied in many domains successfully; however, those algorithms need a PCA transform in advance to avoid a possible singular problem. Further, LGEs are non-orthogonal and this makes them difficult to ...

AIMS To evaluate the prognostic significance of myocardial ischaemia and scar in patients with and without diabetes mellitus (DM) who undergo dobutamine stress cardiac magnetic resonance (DCMR) and late gadolinium enhancement (LGE) imaging for known and suspected coronary artery diseases (CADs). METHODS AND RESULTS A total of 1969 consecutive patients [age 63 ± 12 years, 29% female, left vent...

BACKGROUND Contrast-enhanced cardiac magnetic resonance imaging (CMR) can determine the extent of myocardial scar from infarction (MI). However, the prognostic significance of unrecognized myocardial scar by CMR in patients without a history of MI is unknown. METHODS AND RESULTS One hundred ninety-five patients without a known prior MI underwent CMR for assessment of left ventricular (LV) fun...

BACKGROUND Late gadolinium enhanced cardiovascular magnetic resonance (LGE-CMR) has excellent specificity, sensitivity and diagnostic accuracy for differentiating between ischemic cardiomyopathy (ICM) and non-ischemic dilated cardiomyopathy (NICM). CMR first-pass myocardial perfusion imaging (perfusion-CMR) may also play role in distinguishing heart failure of ischemic and non-ischemic origins,...

The manuscript by Schietinger et al. (1) in this issue of iJACC (JACC: Cardiovascular Imaging) assesses patterns of late gadolinium enhancement (LGE) in the myocardium of chronic hemodialysis patients. The observation that the majority of LGE was not infarct related but was tied to the degree of left ventricular hypertrophy, particularly in dysfunctional segments, led the authors to suggest tha...