The epithelial mesenchymal transition (EMT) has emerged as a pivotal event in the development of the invasive and metastatic potentials of cancer progression. Sorafenib, a VEGFR inhibitor with activity against RAF kinase, is active against hepatocellular carcinoma (HCC); however, the possible involvement of sorafenib in the EMT remains unclear. Here, we examined the effect of sorafenib on the E...

BACKGROUND Epithelial-mesenchymal transition (EMT) is defined as switching of polarized epithelial cells to a migratory fibroblastoid phenotype. EMT is known to be involved in the progression and metastasis of various cancers. The aim was to evaluate that whether EMT-related proteins' alterations are associated with clinicopathological features and prognosis in lung adenocarcinoma. METHODS Th...

We investigate the two-dimensional energy-momentum-tensor (EMT) distributions of nucleon on light front, using Abel transforms three-dimensional EMT ones. explicitly show that main features all are kept intact in course transform. also examine equivalence between global and local conditions for stability Breit frame transverse plane front. discuss force fields inside a

Cancer upregulated gene 2 (CUG2) enhances cell migration and invasion, but the underlying mechanism has not been revealed. Herein, CUG2 decreased the expression of E-cadherin and increased the expression of N-cadherin and vimentin, characteristics of the epithelial-mesenchymal transition (EMT). A CUG2 deletion mutant, lacking interaction with nucleophosmin 1 (NPM1), or suppression of NPM1 reduc...

Recent research into the mechanisms of tumour cell invasiveness has highlighted the parallels between carcinogenesis and epithelial-mesenchymal transition (EMT), originally described as a developmental transdifferentiation program but also implicated in fibrosis and cancer. In a model system for mammary carcinogenesis, we previously observed that induced signalling from a homodimer of the c-erb...

Endothelial-mesenchymal transformation (EMT) is a critical event for the embryonic morphogenesis of cardiac valves. Inducers of EMT during valvulogenesis include VEGF, TGF-β1, and wnt/β-catenin (where wnt refers to the wingless-type mammary tumor virus integration site family of proteins), that are regulated in a spatiotemporal manner. EMT has also been observed in diseased, strain-overloaded v...

MiRNAs emerge as important regulators of epithelial-to-mesenchymal transition (EMT). The Best known EMT regulatory miRNAs are targeting the transcriptional repressors of E-cadherin (E-cad). We identified miR-506 as a key EMT inhibitor through directly targeting the E-cad transcriptional repressor, SNAI2. Our recent studies showed that miR-506 simultaneously suppresses vimentin and N-cad. Thus, ...

Epithelial-mesenchymal transition (EMT) is a central mechanism governing destined cell movement in embryonic development. Emerging evidence reveals that EMT characterizing the progression of many carcinomas is linked to the acquisition of an invasive and metastatic phenotype. While it is established that EMT is controlled by well-conserved mechanisms, additional research is required for various...

The main event is when physiologic EMT is seen in gastrulation; formation and migration of neural crest cells.[3] The progression of EMT is further classified into primary (1°), secondary (2°) and tertiary (3°) EMT,[2] depending on the number or sequential sweeps of EMT and mesenchymal‐epithelial transition (MET).[2] MET signifies the conversion of the mesenchymal phenotype back into the epithe...

Electromagnetic tracking (EMT) is used in several medical fields to determine the position and orientation of dedicated sensors, e.g., attached to surgical tools. Recently, EMT has been introduced to brachytherapy for implant reconstruction and error detection. The manuscript briefly summarizes the main issues of EMT and error detection in brachytherapy. The potential and complementarity of EMT...