Expression of human fos proto-oncogene (c-fos) was analyzed in primary cells from 50 untreated acute lymphocytic (ALL) and myeloblastic (AML) leukemias. c-fos RNA, analyzed by blot hybridization, was detected virtually only in myelomonocytic (M4) and monocytic (M5) AML. Both M4 and M5 samples show a strong positive correlation between the amount of c-fos transcripts and the percentage of leukem...

Two epitopes have been identified recently to be responsible for the high-affinity binding of alkane-bisammonium and caracurine V type allosteric ligands to N-methylscopolamine (NMS)-occupied M2 muscarinic acetylcholine receptors, relative to M5 receptors: the amino acid M2-Thr423 at the top of transmembrane region (TM) 7 and an epitope comprising the second extracellular loop (o2) of the M2 re...

The nuclear receptor co-repressor (N-CoR) is a key component of the generic co-repressor complex that plays an important role in the control of cellular growth and differentiation. As shown by us recently, the growth suppressive function of N-CoR largely relies on its capacity to repress Flt3, a key regulator of cellular gorwth during normal and malignant hematopoesis. We further demonstrated h...

We study the geometry of M5-branes wrapping a 2-cycle which is Special Lagrangian with respect to a specific complex structure in a CalabiYau two-fold. Using methods recently applied to the three-fold case, we are again able find a characterization of the geometry, in terms of a nonintegrable almost complex structure and a (2,0) form. This time, however, due to the hyper-Kähler nature of the un...

Three studies (Ns = 183, 75, 123) examined the utility of the M5 Questionnaire (McCord, 2002), based on the five-factor model of personality (FFM), in assessing psychopathic personality traits in three separate undergraduate college student samples from the same public university in the Southeastern United States. Participants completed the M5 Questionnaire, a 336-item FFM instrument derived fr...