نتایج جستجو برای: رویکرد in silico

تعداد نتایج: 17020617  

2004
Ki-Hwan Lee Ki-Seok Jeon Seung-Koo Lee Chang-Shik Choi

We have systematically studied the evolution of the photoluminescence(PL) tuning of porous silicon(PS) by electrochemical etching in various mixed electrolytes. The electrolytes employed as an etchants were mixtures of HF:CH3COOH:HNO3:C2H5OH solutions where the composition ratios (%) were varied from 10:1.98:0:88.02 to 10:1.98:8.4:79.62 under constant concentration of HF and CH3COOH with a tota...

ژورنال: Iranian Biomedical Journal 2018
Mortazavi, Yousef, Payandeh, Zahra, Rahimpour, Azam, Rajabibazl, Masoumeh, Taromchi, Amir Hossein,

Background: Ofatumumab, an anti-CD20 mAb, was approved in 2009 for the treatment of chronic lymphocytic leukemia. This mAb acts through immune-mediated mechanisms, in particular complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity by natural killer cells as well as antibody-dependent phagocytosis by macrophages. Apoptosis induction is another mechanism of this antibody...

Journal: :Drug Discovery Today: Disease Models 2007

2015
Seddik Hammad Mosaab A. Omar Mohammed F. Abdallah Hassan Ahmed

1 Department of Forensic Medicine and Veterinary Toxicology, Faculty of Veterinary Medicine, South Valley University, 83523 Qena-Egypt 2 Department of Medical Laboratories, Collage of Applied Medical Sciences, Majmaah University-Kingdom of Saudi Arabia 3 Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Sıhyyie/Ankara-Türkiye 4 Division of Cerebral Circuitry, N...

2016
Neeraj Kumar Shashank Shekhar Mishra Chandra Shekhar Sharma Hamendra Pratap Singh

Malaria, one of the most widespread diseases, is caused by a plasmodium parasite million people each year, results in several million deaths annually. protozoa that cause malaria, no one antimalarial drug is effective against all four species. research investigation, we performed antimalarial agents. To design a new molecule having good pha information. Key-words: TPSA, GPCR, ADMETox, Malaria i...

Journal: :Current Biology 1997
Sean Cutler Chris Somerville

Cell walls are of interest to plant biochemists and cell biologists for two main reasons: they regulate cellular morphogenesis and act as structural support materials. As it is a major component of plant cell walls and a natural product of considerable commercial value, cellulose has long been a focus of interest in cell-wall biology, although it is far from the only constituent of cell walls. ...

Journal: :Genome informatics. International Conference on Genome Informatics 2002
Sang Yup Lee Soon Ho Hong Soo Yun Moon

The intracellular metabolic fluxes can be calculated by metabolic flux analysis, which uses a stoichiometric model for the intracellular reactions along with mass balances around the intracellular metabolites. In this study, we have constructed in silico metabolic pathway network of Escherichia coli consisting of 301 reactions and 294 metabolites. Metabolic flux analyses were carried out to est...

2012
Jacob D. Durrant James Andrew McCammon

Academic researchers and many in industry often lack the financial resources available to scientists working in "big pharma." High costs include those associated with high-throughput screening and chemical synthesis. In order to address these challenges, many researchers have in part turned to alternate methodologies. Virtual screening, for example, often substitutes for high-throughput screeni...

Journal: :Genome research 2011
Valliammai Muthappan Aaron Y Lee Tamara L Lamprecht Lakshmi Akileswaran Suzanne M Dintzis Choli Lee Vincent Magrini Elaine R Mardis Jay Shendure Russell N Van Gelder

Metagenomic characterization of complex biomes remains challenging. Here we describe a modification of digital karyotyping-biome representational in silico karyotyping (BRISK)-as a general technique for analyzing a defined representation of all DNA present in a sample. BRISK utilizes a Type IIB DNA restriction enzyme to create a defined representation of 27-mer DNAs in a sample. Massively paral...

پلی­ آمین اکسیدازها (PAO) آنزیم­های وابسته به فلاوین آدنین دی­نوکلئوتید هستند که در کاتابولیسم پلی­آمین­ها در پراکسی­ زوم، آپوپلاست و سیتوپلاسم نقش دارند. گزارش­های زیادی در زمینه اهمیت ژن­های PAO گیاهان در پاسخ به تنش­ها ارائه شده است با این حال مطالعه جامعی در مورد تعداد، روابط تکاملی، ساختار ژنی و الگوی بیانی ژن­های PAO در انگور موجود نیست. در مطالعه حاضر با استفاده از روش­های بیوانفورماتیکی...

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