Three surgeons operated on upper eye lids of northern Omani villagers for trichiasis due to trachoma using a standardised protocol. The lids were graded as minor trichiasis, five or fewer lashes; major trichiasis, six or more lashes; and lid closure defect. Operative success was defined as no lash/eyeball contact and complete gentle lid closure. One hundred and sixty five lids with major trichi...

BACKGROUND The techniques of lower blepharoplasty are evolving to reflect the concept that the lower eyelid contour does not stop at the inferior orbital rim, and that the lid-cheek junction must often be modified to restore the midface to a youthful configuration. Multiple procedures have been proposed to smooth the lid-cheek junction and tear trough. The author proposes a technique of carbon ...

Prevention and treatment of abnormal scarring present a challenge to the medical fraternity. Herein, we report the beneficial effect of botulinum toxin A (BTA) for wound modulation in a case with post‐traumatic lower lid cicatricial ectropion. A 20‐year‐old male patient presented with severe cicatricial ectropion in his left lower lid with a scar going down to his cheek and to the ala of the no...

The proteasome is assembled via the nine-subunit lid, nine-subunit base, and 28-subunit core particle (CP). Previous work has shown that the chaperones Rpn14, Nas6, Hsm3, and Nas2 each bind a specific ATPase subunit of the base and antagonize base-CP interaction. Here, we show that the Nas6 chaperone also obstructs base-lid association. Nas6 alternates between these two inhibitory modes accordi...

In an attempt to restrict drug absorption from suppositories to only the lower rectum, mucoadhesive lidocaine (LID) suppositories were prepared using WitepsolR H-15 as a base, and CarbopolR 934p (CP) and white beeswax (WAX) as additives. CP has a mucoadhesive property and WAX gives the suppositories stiffness. The suppositories containing 109{(, CP and 20% WAX stayed in the lower recta of rats ...

Dynamic regulation of histone modifications is critical during development, and aberrant activity of chromatin-modifying enzymes has been associated with diseases such as cancer. Histone demethylases have been shown to play a key role in eukaryotic gene transcription; however, little is known about how their activities are coordinated in vivo to regulate specific biological processes. In Drosop...

Fractional continuous wave CO2 laser resurfacing is used to improve photodamage, wrinkles, and acne scarring by surface ablation and by using heat to activate natural collagen production and dermal remodeling. In this study, the author examined the efficacy and safety of nonincisional continuous wave fractional CO2 laser blepharoplasty in the upper lid. Standard lid measurements including margi...

Deep Neural Networks (DNNs) have recently been shown to be vulnerable against adversarial examples, which are carefully crafted instances that can mislead DNNs to make errors during prediction. To better understand such attacks, the properties of subspaces in the neighborhood of adversarial examples need to be characterized. In particular, effective measures are required to discriminate adversa...

Currently, continued urbanization and development result in an increase of impervious areas and surface runoff including pollutants. Also one of the greatest issues in pollutant emissions is the first flush effect (FFE), which implies a greater discharge rate of pollutant mass in the early part in the storm. Low impact development (LID) practices have been mentioned as a promising strategy to c...

Liver IGF-1 deficient (LID) mice demonstrate a 75% reduction in circulating IGF-1 levels and a corresponding fourfold increase in growth hormone (GH) levels. At 16 weeks of age, LID mice demonstrate, using the hyperinsulinemic-euglycemic clamp, insulin insensitivity in muscle, liver, and fat tissues. In contrast, mice with a gene deletion of the acid-labile subunit (ALSKO) demonstrate a 65% red...