AIM To explore the relationship between alteration in the expression of TWIST, highly conserved transcription factor from the basic helix-loop-helix family, and apoptosis of Hep-2 cells induced by chemotherapeutic agent paclitaxel. METHODS Morphological changes of Hep-2 cells were observed by acridine orange cytochemistry staining. Viability of Hep-2 cells treated with various concentrations ...

In the present study, we investigated the mechanisms of chamaejasmine action on human HEp-2 larynx carcinoma cells, which possess constitutively active Akt. Results indicated that chamaejasmine showed more notable anticancer activity than apigenin against HEp-2, PC-3, NCI-H1975, HT-29 and SKOV-3. Moreover, chamaejasmine presented most significantly inhibition towards HEp-2, with IC₅₀ values of ...

BACKGROUND Telomere length is closely associated with cellular radiosensitivity and WRAP53 is required for telomere addition by telomerase. In this research we assessed radiosensitivity of laryngeal squamous cell carcinoma Hep-2 cell lines after WRAP53 inhibition, and analyzed the molecular mechanisms. MATERIALS AND METHODS phWRAP53-siRNA and pNeg-siRNA were constructed and transfected into H...

OBJECTIVE To describe challenges in disseminating the Health Enhancement Program (HEP), a community-based disability prevention program for community dwelling elders, and to examine program effectiveness in geographically dispersed sites. METHODS Within-group, pre-test-post-test comparisons of disability risk factors, health and functional status, and hospitalizations for 115 participants com...

Hepatocyte paraffin 1 (Hep Par 1), a monoclonal antibody recognizing an antigen thought to be specific for hepatocyte mitochondria, is considered the most specific and sensitive marker of normal and neoplastic hepatocytes and has been used in diagnosing hepatocellular carcinomas. Recent data suggest that the specificity of Hep Par 1 for hepatic neoplasms is not absolute; nonhepatic neoplasms mi...

هدف: این پژوهش با هدف بررسی اثر آموزش برنامه هوش موفق استرنبرگ بر افزایش خلاقیت و تحمل ابهام دانش‌­آموزان انجام شد. روش: روش ­آزمایشی طرح پیش ­آزمون پس پیگیری گروه کنترل بود. جامعۀ آماری را 15842 نفر ازدانش‌­آموزان پسر کلاس چهارم در سال تحصیلی1399-1400 شهر اصفهان تشکیل دادند که30 نمونه‌­گیری تصادفی چند مرحله­‌ای انتخاب به صورت دو آزمایش (15 نفر) گمارده شدند. ده جلسه برنامه‌­ی دریافت نمود. داده­...

Analogous to the fraction unbound in microsomes (fu(mic)), fraction unbound in hepatocyte incubations (fu(hep)) is an important parameter in the prediction of intrinsic clearance and potential drug-drug interactions. A recent study by Austin et al. (Drug Metab Dispos 33:419-425, 2005) proposed a linear 1:1 relationship between the extent of binding to microsomes at 1 mg/ml and to hepatocytes at...

Serum opacity factor (SOF) is a bifunctional cell surface protein expressed by 40-50% of group A streptococcal (GAS) strains comprised of a C-terminal domain that binds fibronectin and an N-terminal domain that mediates opacification of mammalian sera. The sof gene was recently discovered to be cotranscribed in a two-gene operon with a gene encoding another fibronectin-binding protein, sfbX. We...

In a typical cell culture system, growth factors immobilized on the cell culture surfaces can serve as a reservoir of bio-signaling molecules, without the need to supplement them additionally into the culture medium. In this paper, we report on the fabrication of albumin/heparin (Alb/Hep) assemblies for controlled binding of basic fibroblast growth factor (FGF-2). The surfaces were constructed ...

The symmetric dimeric complex [Cu(mu(2)-hep)(TFA)(H(2)O)](2) (1) has been synthesized from 2-(2-hydroxyethyl)pyridine (hep-H), trifluoroacetic acid (TFA-H), and copper acetate in a 95:5 (v/v) MeOH-H(2)O mixture at 298 K. Each Cu(II) ion in 1 is linked with two mu(2)-alcoholic oxygen atoms and one pyridine nitrogen atom of hep, and the other two coordination sites are occupied by the oxygen dono...