نتایج جستجو برای: روش طرحریزی رابطه خاکستری grp
تعداد نتایج: 411208 فیلتر نتایج به سال:
Development of cancer receptor-specific gold nanoparticles will allow efficient targeting/optimum retention of engineered gold nanoparticles within tumors and thus provide synergistic advantages in oncology as it relates to molecular imaging and therapy. Bombesin (BBN) peptides have demonstrated high affinity toward gastrin-releasing peptide (GRP) receptors in vivo that are overexpressed in pro...
Gastrin releasing-peptide (GRP) is a potent growth factor in many malignancies. Benign prostatic hyperplasia (BPH) is a progressive age-related proliferation of glandular and stromal tissues; various growth factors and inflammatory processes are involved in its pathogenesis. We have demonstrated that potent antagonists of GRP inhibit growth of experimental human tumors including prostate cancer...
A direct Eulerian generalized Riemann problem (GRP) scheme is derived for compressible fluid flows. Riemann invariants are introduced as the main ingredient to resolve the generalized Riemann problem (GRP) directly for the Eulerian formulation. The crucial auxiliary Lagrangian scheme in the original GRP scheme is not necessary in the present framework. The delicate sonic cases can be easily tre...
Bombesin (BN) or gastrin-releasing peptide (GRP) can stimulate the growth of neoplasms such as breast cancer and small-cell lung carcinoma (SCLC). Antagonists of BN/GRP have been shown to inhibit these cancers. We evaluated whether antagonists of BN/GRP can suppress the growth of human non-SCLC (NSCLC) xenografted into nude mice. The effect of the administration of BN/GRP antagonist RC-3940-II ...
در مطالعه حاضر، با استفاده از مدل تصمیم گیری چند معیاره تعاملی (روش مرحله ای) و برنامه ریزی فازی خاکستری به تخصیص بهینه منابع آب در بخش های مختلف کشاورزی، صنعت، شرب و فضای سبز در شهرستان یزد پرداخته شد. هدف از این تحقیق حداکثرکردن منافع اقتصادی و زیست محیطی در تخصیص منابع آب می باشد. داده های مورد نیاز از شرکت سهامی آب منطقه ای، سازمان آب و فاضلاب، جهاد کشاورزی و سازمان صنعت، معدن و تجارت استان...
It is shown how to transform the General Routing Problem (GRP) into a variant of the Graphical Travelling Salesman Problem (GTSP). This transformation yields a projective characterisation of the GRP polyhedron. Using this characterisation, it is shown how to convert facets of the GTSP polyhedron into valid inequalities for the GRP polyhedron. The resulting classes of inequalities subsume severa...
Gastrin-releasing peptide receptor (GRPR) and the epidermal growth factor receptor (EGFR) are expressed in several cancers including non-small cell lung cancer (NSCLC). Here we demonstrate the activation of EGFR by the GRPR ligand, gastrin-releasing peptide (GRP), in NSCLC cells. GRP induced rapid activation of p44/42 MAPK in lung cancer cells through EGFR. GRP-mediated activation of MAPK in NS...
Antiangiogenic effects of the proteasome inhibitor bortezomib were analyzed on tumor xenografts in vivo. Bortezomib strongly inhibited angiogenesis and vascularization in the chicken chorioallantoic membrane. Bortezomib's inhibitory effects on chorioallantoic membrane vascularization were abrogated in the presence of distinct tumor xenografts, thanks to a soluble factor secreted by tumor cells....
Gastrin releasing peptide (GRP), the human homologue of bombesin (BN), is an autocrine growth factor for small cell lung cancer (SCLC) cells. The synthetic octapeptides [D-cpa1-beta-Leu8-des-Met9]litorin (BIM 26182) and [D-Phe6-Leu13-CH2NH-Cpa14]bombesin(6-14)NH2 (BIM 26189) are potent GRP/BN antagonists of the proliferation of 3T3 and rat pancreas cells. The effect of these analogues on the pr...
The paper proposes to intend the firm as a “nexus of stakeholders”, each bearing return-to-risk expectations about sharing corporate performance. All stakeholders must achieve their own satisfaction through bargaining contracts that be sustainable, i.e., keep both and its stakeholders-network alive in long term. Governance is intended mechanism gives solution above puzzle. When market are compl...
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