Recent studies in laboratory rodents have revealed that circadian oscillation in the physiologic functions affecting drug disposition underlies the dosing time-dependent change in pharmacokinetics. However, it is difficult to predict the circadian change in the drug pharmacokinetics in a diurnal human by using the data collected from nocturnal rodents. In this study, we used cynomolgus monkeys,...

The goal of this study was to provide a reasonable assessment of how probe substrate selection may impact the results of in vitro aldehyde oxidase (AO) inhibition experiments. Here, we used a previously studied set of seven known AO inhibitors to probe the inhibition profile of a pharmacologically relevant substrate N-[(2dimethylamino)ethyl]acridine-4-carboxamide (DACA). DACA oxidation in human...

The goal of this study was to provide a reasonable assessment of how probe substrate selection may impact the results of in vitro aldehyde oxidase (AO) inhibition experiments. Here, we used a previously studied set of seven known AO inhibitors to probe the inhibition profile of a pharmacologically relevant substrate N-[(2dimethylamino)ethyl]acridine-4-carboxamide (DACA). DACA oxidation in human...

The goal of this study was to provide a reasonable assessment of how probe substrate selection may impact the results of in vitro aldehyde oxidase (AO) inhibition experiments. Here, we used a previously studied set of seven known AO inhibitors to probe the inhibition profile of a pharmacologically relevant substrate N-[(2dimethylamino)ethyl]acridine-4-carboxamide (DACA). DACA oxidation in human...

ITE JOURNAL / AUGUST 1999 PEDESTRIAN ZONES HAVE become a familiar feature in the central areas of European cities. Private cars are always excluded from these zones, while delivery vehicles are permitted during off-peak hours. Bicycles and taxis are typically relegated to a circumferential service road. Some have argued that such rigid traffic separation contributes to economic and environmenta...

The goal of this study was to provide a reasonable assessment of how probe substrate selection may impact the results of in vitro aldehyde oxidase (AO) inhibition experiments. Here, we used a previously studied set of seven known AO inhibitors to probe the inhibition profile of a pharmacologically relevant substrate N-[(2dimethylamino)ethyl]acridine-4-carboxamide (DACA). DACA oxidation in human...

1.1 Overview on pneumoconioses Pneumoconiosis is an occupational lung disease caused by the exposure to dust. This section summarizes the generalities on pneumoconioses, including definitions, epidemiology and clinical manifestations of those occupational and environmental lung diseases. The most important step in the diagnosis of pneumoconiosis in to question the subject regarding specifics of...

DirectDemocracyP2P (ddp2p.net) provides an environment for electronic debates, moderated in a decentralized way by ordering justifications (aka comments) based on collaborative filtering. The intuition was that comment threading models for such systems ought to have the peculiarity that each user should be allowed to submit a single justification when voting for a given motion, unlike common fo...