نتایج جستجو برای: رسپتور grp

تعداد نتایج: 1944  

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2002
Wouter A P Breeman Marion de Jong Jack L Erion Joseph E Bugaj Ananth Srinivasan Bert F Bernard Dik J Kwekkeboom Theo J Visser Eric P Krenning

UNLABELLED The 14-amino-acid peptide bombesin (BN) has a high affinity for the gastrin-releasing peptide (GRP) receptor that is expressed by a variety of tumors. Recently, high densities of GRP receptors were identified by in vitro receptor autoradiography in human prostate and breast carcinomas using [(125)I-Tyr(4)]BN as radioligand. Radiometal-labeled diethylenetriaminepentaacetic acid (DTPA)...

Journal: :The Journal of biological chemistry 1991
M H Corjay D J Dobrzanski J M Way J Viallet H Shapira P Worland E A Sausville J F Battey

Bombesin-like peptides have been implicated as autocrine growth factors influencing the pathogenesis and progression of some human lung carcinoma cells. To determine the pharmacologic and structural properties of the bombesin receptors expressed in human lung carcinoma cells, cDNA clones encoding a human gastrin-releasing peptide receptor (GRP-R) and a pharmacologically distinct neuromedin-B pr...

Journal: :Cell 2002
Gleb P. Shumyatsky Evgeny Tsvetkov Gaël Malleret Svetlana Vronskaya Michael Hatton Lori Hampton James F. Battey Catherine Dulac Eric R. Kandel Vadim Y. Bolshakov

We identified the Grp gene, encoding gastrin-releasing peptide, as being highly expressed both in the lateral nucleus of the amygdala, the nucleus where associations for Pavlovian learned fear are formed, and in the regions that convey fearful auditory information to the lateral nucleus. Moreover, we found that GRP receptor (GRPR) is expressed in GABAergic interneurons of the lateral nucleus. G...

2005
JOHN R. FREDERIKSEN

Ss were asked to identify ambiguous auditory and visual stimuli (words and pictures), each of which was presented for a series of consecutive trials. On successive trials, the degree of ambiguity (auditory masking or amount of blur) was reduced, so that on the final presentation, the stimulus was easily recognizable. The Ss were divided into 2 grps.; the WRA (wide range of ambiguity) grp. was g...

2016
Nao KATAYAMA Takumi OTI Keiko TAKANAMI Tatsuya SAKAMOTO Hirotaka SAKAMOTO

A sexually dimorphic spinal gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord, which projects to the lower spinal centers, controls erection and ejaculation in rats. However, little is known about the postnatal development of this system. In this study, we therefore examined the postnatal development of the male-dominant spinal GRP system and its sexual differentiation in ra...

Journal: :Neuron 2017
Shuohao Sun Qian Xu Changxiong Guo Yun Guan Qin Liu Xinzhong Dong

Coding of itch versus pain has been heatedly debated for decades. However, the current coding theories (labeled line, intensity, and selectivity theory) cannot accommodate all experimental observations. Here we identified a subset of spinal interneurons, labeled by gastrin-releasing peptide (Grp), that receive direct synaptic input from both pain and itch primary sensory neurons. When activated...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1998
L L Hampton E E Ladenheim M Akeson J M Way H C Weber V E Sutliff R T Jensen L J Wine H Arnheiter J F Battey

The gastrin-releasing peptide receptor (GRP-R) is one of three members of the mammalian bombesin subfamily of seven-transmembrane G protein-coupled receptors that mediate diverse biological responses including secretion, neuromodulation, chemotaxis, and growth. The X chromosome-linked GRP-R gene is expressed widely during embryonic development and predominantly in gastrointestinal, neuronal, an...

Journal: :The Astrophysical Journal 2023

Precise interstellar dust extinction laws are important to infer the intrinsic properties of reddened objects and correctly interpret observations. In this work, we attempt measure optical--infrared Large Small Magellanic Clouds (LMC SMC) by using red supergiant (RSG) stars classical Cepheids as tracers. The spectroscopic RSG samples constructed based on APOGEE spectral parameters, Gaia astrome...

2012
André W. Phillips Sina Falahati Roshi DeSilva Irina Shats Joel Marx Edwin Arauz Douglas A. Kerr Jeffrey D. Rothstein Michael V. Johnston Ali Fatemi

This is a protocol for derivation of glial restricted precursor (GRP) cells from the spinal cord of E13 mouse fetuses. These cells are early precursors within the oligodendrocytic cell lineage. Recently, these cells have been studied as potential source for restorative therapies in white matter diseases. Periventricular leukomalacia (PVL) is the leading cause of non-genetic white matter disease...

Journal: :The Journal of biological chemistry 1990
R I Feldman J M Wu J C Jenson E Mann

The bombesin/gastrin-releasing peptide (GRP) receptor was solubilized from Swiss mouse 3T3 cell membranes in an active form and was purified about 90,000-fold to near homogeneity by a combination of wheat germ agglutinin-agarose and ligand affinity chromatography. The purified receptor displayed a single diffuse band with a Mr of 75,000-100,000 on sodium dodecyl sulfate-polyacrylamide gel elect...

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