We study the quotient complex ∆(B lm)/S l ≀ Sm as a means of deducing facts about the ring k[x 1 ,. .. , x lm ] S l ≀Sm. It is shown in [He] that ∆(B lm)/S l ≀ Sm is shellable when l = 2, implying Cohen-Macaulayness of k[x 1 ,. .. , x 2m ] S 2 ≀Sm for any field k. We now confirm for all pairs (l, m) with l > 2 and m > 1 that ∆(B lm)/S l ≀ Sm is not Cohen-Macaulay over Z Z/2Z Z, but it is Cohen-...

Hfq and other Sm proteins are central in RNA metabolism, forming an evolutionarily conserved family that plays key roles in RNA processing in organisms ranging from archaea to bacteria to human. Sm-based cellular pathways vary in scope from eukaryotic mRNA splicing to bacterial quorum sensing, with at least one step in each of these pathways being mediated by an RNA-associated molecular assembl...

OBJECTIVE Three fractions (SM, SM-A, SM-B) were prepared from different polarity parts of Ipomoea batatas Lam. (cv.simon) leaves and the anti-tumor potency as well as the dose-response relations were evaluated. METHODS The anti-tumor activities of fraction SM, SM-A or SM-B were screened by MTS in human hepatic cancer Hep3B cells, lung cancer A549 cells or gastric carcinoma MGC803 cells, respe...

Three clinical isolates, K-Ps 94, K-Ps 97 and K-Ps 102, of Pseudomonas aeruginosa having R factor and showing MIC of more than 51,200 mcg/ml to streptomycin (SM), were examined for mechanisms of SM-resistance. Among the strains, K-Ps 94 and K-Ps 102 had R factor conferring SM-resistance. In K-Ps 94, the mechanism of SM-resistance was mainly owing to SM-phosphorylating enzyme and also owing to d...

Systemic mastocytosis (SM) is characterized by the abnormal proliferation and accumulation of mast cells (MCs). Constitutive activation of kit, a receptor tyrosine kinase (TK), has been associated with all types of SM. Signal transducers and activators of transcription (STATs), such as STAT5, mediate downstream kit signalling. We hypothesized that nuclear phospho-STAT5 (pSTAT5) in MCs might ref...

Sphingomyelin (SM) is an abundant phospholipid in cell membranes and in lipoproteins. In human plasma, SM is mainly found in atherogenic lipoproteins; therefore, higher levels of SM may promote atherogenesis. We investigated the relations between plasma SM levels and the presence of angiographic coronary heart disease (CHD) and left ventricular systolic dysfunction. We studied 732 patients refe...

A new antibiotic, named seitomycin (1c), and the known microbial metabolite tetrangulol methyl ether (2) were found in the ethyl acetate extract of two terrestrial Streptomyces sp. isolates. The structure of the new antibiotic was elucidated by spectroscopic studies and by comparison of the NMR data with the structurally related hatomarubigin C (1a) and SM-196 B (1b). Seitomycin (1c) showed mod...

Sympathetic neurons undergo protein synthesis-dependent apoptosis when deprived of nerve growth factor (NGF). Expression of SM-20 is up-regulated in NGF-deprived sympathetic neurons, and ectopic SM-20 is sufficient to promote neuronal death in the presence of NGF. We now report that SM-20 is a mitochondrial protein that promotes cell death through a caspase-dependent mechanism. SM-20 immunofluo...