Background: The Presence of donor leukocytes in recipients of organ allograft has been shown even several years after transplantation. However, it remains unclear whether this donor cell microchimerism plays an effective role in allograft acceptance or is simply a consequence of immunosuppressive conditions in recipients. Objective: To study microchimerism in a group of kidney transplant recipi...

Background: Alzheimer’s disease’s (AD) prevalence is projected to increase as the population ages and current treatments are minimally effective. Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light penetrates into cerebral cortex, stimulates mitochondrial respiratory chain, increases blood flow. Preliminary data suggests t-PBM may be efficacious in improving cognition people ...

The conventional model of the day-ahead electricity markets employs an energy-based approach to manage competition among players. Under this format, it is assumed that everything (including demand and output power generating units) constant during each hour. This assumption greatly simplifies market, widely incorporated over globe. However, leads mismatches in real-time operation. With increase...

BACKGROUND Autologous blood transfusion (ABT) is currently considered the safest transfusion, since the risks of allogeneic immunological reaction and viral transmission are theoretically null. Although its use has declined in Western countries in the recent decade, it has been progressively expanded in Japan. With the widening of the concept of patient blood management (PBM), which aims to pre...

Platelet-endothelial cell adhesion molecule (PECAM)-1 has been implicated in leukocyte migration through the perivascular basement membrane (PBM) though the mechanisms involved are unclear. The present results demonstrate that the ability of 6 integrins to mediate neutrophil migration through the PBM is PECAM-1 dependent, a response associated with PECAM-1– mediated increased expression of 6 1 ...

Cervical cancer develops through the combined activities of the human papillomavirus (HPV) E6 and E7 oncoproteins. A defining characteristic of E6 oncoproteins derived from cancer-causing HPV types is the presence of a PDZ binding motif (PBM) at the extreme carboxy terminus of the protein which is absent from E6 proteins derived from the so-called low-risk HPV types. Within this PBM is also a p...

The pathogenesis of HIV-1 infection is influenced by the immunoregulatory responses of the host. Macrophages present in the lymphoid tissue are susceptible to infection with HIV-1, but are relatively resistant to its cytopathic effects and serve as a reservoir for the virus during the course of disease. Previous investigators have demonstrated that increased serum levels of TNF-alpha contribute...

Regional and local sources contributing to gaseous elemental mercury (GEM), gaseous oxidized mercury (GOM), and particle-bound mercury (PBM) at an urban coastal site in Dartmouth, Nova Scotia, Canada were investigated using the Concentration-Weighted Trajectory model (CWT) and Conditional Probability Function. From 2010–2011, GEM, GOM, and PBM concentrations were 1.67± 1.01 ng m−3, 2.07± 3.35 p...

PURPOSE The goals of this study were to measure inter- and intrafraction setup error and prostate bed motion (PBM) in patients undergoing post-prostatectomy image-guided radiotherapy (IGRT) and to propose appropriate population-based three-dimensional clinical target volume to planning target volume (CTV-PTV) margins in both non-IGRT and IGRT scenarios. METHODS AND MATERIALS In this prospecti...

BACKGROUND Dihydropyrimidine dehydrogenase (DPD) catalyzes the degradation of thymine, uracil, and the chemotherapeutic drug 5-fluorouracil. To identify patients suffering from complete or partial DPD deficiency and to identify pitfalls that can preclude the proper diagnosis of patients with partial DPD deficiency, a sensitive and accurate assay is necessary. METHODS The activity of DPD was m...