pharmacy benefit managers (PBMs) and health plans to pursue various cost-control methods and interventions, including therapeutic interchange (TI). The practice of TI relies on the conversion of one drug to a different drug within the same therapeutic class to reduce the cost of drug therapy without compromising therapeutic efficacy or safety. More than 50% of employers reported the use of TI i...

We propose titanium-decorated graphene oxide (Ti-GO) as an ideal sorbent for carbon monoxide (CO) capture and separation from gas mixtures. Based on first-principles calculations, Ti-GO exhibits a large binding energy of ~70 kJ mol(-1) for CO molecules, while the binding energies for other gases, such as N(2), CO(2), and CH(4), are significantly smaller. The gas adsorption properties of Ti-GO a...

Multifunctional materials with more than two good properties are widely required in modern industries. However, some properties are often trade-off with each other by single microstructural designation. For example, nanostructured materials have high strength, but low ductility and thermal stability. Here by means of spark plasma sintering (SPS) of nitrided Ti particles, we synthesized bulk cor...

Ti-MCM-41 was synthesized at pH 3, 7 and 11. The titanium content was determined by AAS and found to be 4%, 3.2% and 4.5%, respectively. In order to increase the titanium content in Ti-MCM-41, Ti(IV) ions were grafted onto TiMCM-41 using TiCl4 in toluene and Ti(OBu)4 in ethanol. The incorporation of Ti was determined to be 28% and 30%, respectively. The oxidation of olefins such as cyclopentene...

Esta pesquisa investiga os efeitos do conhecimento compartilhado entre as áreas de TI e de negócios, e dos recursos e capacidades de TI no alinhamento operacional entre estas áreas e, consequentemente, no desempenho de processos de negócio. O estudo se baseia em dados coletados junto às áreas de TI e de retagurada (Back Office) de 36 empresas do Rio de Janeiro, que atuam em diferentes setores. ...

We describe methods and algorithms for automated generation of multiparted airplane wings with winglets. The wings are given by one or more cross-sections (e.g. by point clouds) and their top views. The relative thickness of the wing (thickness/chord) can be varied from section to section. A rounded tip with design parameters and GC1-continuity at the crossing to the wing is automatically compu...

Background In recent years, scaling up of antiretroviral therapy (ART) in resource-limited settings moved impressively towards universal access. Along with these achievements, public health HIV programs are facing a number of challenges including the support of patients on lifelong therapy and the prevention of temporary/permanent loss of patients in care. Understanding reasons for treatment in...

Structured light plethysmography (SLP) is a noncontact, noninvasive, respiratory measurement technique, which uses a structured pattern of light and two cameras to track displacement of the thoraco-abdominal wall during tidal breathing. The primary objective of this study was to examine agreement between tidal breathing parameters measured simultaneously for 45 sec using pneumotachography and S...

Deoxidation of Ti, or direct removal of O dissolved in metallic Ti, is known to be extremely difficult when Mg is used as the deoxidizing agent. This difficulty arises because the chemical potential of O2, pO2, under Mg/MgO equilibrium is high (approximately 10(-41) atm at 1200 K) and is equivalent to that of Ti containing ∼2 mass% O at 1200 K. Therefore, when deoxidizing Ti to the commercial l...

Previous studies have demonstrated that the modification of the titanium (Ti) surface of an implant with RGD (Arg‑Gly‑Asp) promotes the activity of osteoblasts. A novel Ti‑binding peptide, minTBP‑1, and a chimeric peptide, minTBP‑1‑PRGDN, have been synthesized to assist the fixing of RGD to Ti. In our previous study, minTBP‑1‑PRGDN demonstrated favorable affinity for Ti surfaces and facilitated...