Near total laryngectomy can be safely combined with partial or subtotal pharyngectomies when the disease is lateralized rendering the interarytenoid joint and the contralateral cricoarytenoid joint free of tumor. A case of post radiotherapy recurrent carcinoma of the posterior pharyngeal wall which could be salvaged by a circumferential pharyngectomy combined with a near total laryngectomy is r...

We present a case of a near total amputation at the distal tibial level, in which the patient emphatically wanted to save the leg. The anterior and posterior tibial nerves were intact, indicating a high possibility of sensory recovery after revascularization. The patient had open fractures at the tibia and fibula, but no bone shortening was performed. The posterior tibial vessels were reconstru...

BACKGROUND The treatment of unicompartmental arthritis in younger patients is challenging. The aim of this study is to report final safety and efficacy analysis results for the iForma patient-specific interpositional device, which is designed for the treatment of isolated medial or lateral compartment arthritis of the knee. METHODS From June 2005 to June 2008 78 subjects (42 men, 36 women) re...

Protein alignments are commonly used to evaluate the similarity of protein residues, and the derived consensus sequence used for identifying functional units (e.g., domains). Traditional consensus-building models fail to account for interpositional dependencies - functionally required covariation of residues that tend to appear simultaneously throughout evolution and across the phylogentic tree...