Despite the investments in malaria research, an effective vaccine has not yet been developed and the causative parasites are becoming increasingly resistant to most of the available drugs. PfATP6, the sarco/endoplasmic reticulum Ca2+ pump (SERCA) of P. falciparum, has been recently genetically validated as a potential antimalarial target and cyclopiazonic acid (CPA) has been found to be a poten...

We propose a scheme for controlling nonlinear coherent perfect absorption (CPA) in three-level \Lambda-type atom-cavity system. Generally, the normally CPA and bistable can be attained at different frequencies of an input probe field. With control field coupling one ground states excited state atoms, two types same frequency. Besides, CPA, highest output-input ratio high stable low is approxima...

This study investigated the effects of bilateral intraamygdalar microinjections of PNU-282987, a nicotinic cholinergic agonist, on anxiety and the reversal of amnesia induced by chlorpheniramine (CPA), an H1 histaminergic antagonist, in mice subjected to the elevated plusmaze (EPM). Two experiments were performed with seventy-nine adult male Swiss mice. The isolated microinjections of PNU-28298...

In the central nervous system, cerebellopontine angle (CPA) lymphomas are rare; few cases have been reported. Lymphoplasmacytic lymphoma (LPL) in the CPA is rarer still, and often misdiagnosed as acoustic neuroma.We report a rare case of CPA LPL-a challenging diagnosis guided by clinical presentations, radiological signs, and postoperative pathological test.A 43-year-old woman presented with he...

In this paper, we build on the idea of Citation Proximity Analysis (CPA), originally introduced in [1], by developing a step by step scalable approach for building CPA-based recommender systems. As part of this approach, we introduce three new proximity functions, extending the basic assumption of co-citation analysis (stating that the more often two articles are co-cited in a document, the mor...

The sensitivity of cultured L1210 and P388 cells, sensitive (L1210/0, P388/0) and resistant (L1210/CPA, P388/CPA) to cyclophosphamide in vivo, to five oxazaphosphorine and eight nonoxazaphosphorine cross-linking agents was determined. Each of the resistant sublines was cross-resistant to all of the oxazaphosphorines tested. The P388/CPA cell line was also cross-resistant to all of the nonoxazap...

Applications of the Covering Property Axiom Andrés Millán Millán The purpose of this work is two-fold. First, we present some consequences of the Covering Property Axiom CPA of Ciesielski and Pawlikowski which captures the combinatorial core of the Sacks’ model of the set theory. Second, we discuss the assumptions in the formulation of different versions of CPA. As our first application of CPA ...

Cyclophosphamide (CPA), a widely used oxazaphosphorine anti-cancer prodrug, is inactive until it is metabolized by cytochrome P450 to yield phosphoramide mustard and acrolein, which alkylate DNA and proteins, respectively. Tumor cells transduced with the human cytochrome P450 gene CYP2B6 are greatly sensitized to CPA, however, the pathway of CPA-induced cell death is unknown. The present study ...

In clinical trials, metronomic cyclophosphamide (CPA) is increasingly being combined with vaccines to reduce tumor-induced immune suppression. Previous strategies to modulate the immune system during vaccination have involved continuous administration of low dose chemotherapy, studies that have posed unique considerations for clinical trial design. Here, we evaluated metronomic CPA in combinati...

OBJECTIVE This research examined linkages between exposure to childhood sexual abuse (CSA) and childhood physical punishment/abuse (CPA) and mental health issues in early adulthood. METHOD The investigation analyzed data from a birth cohort of over 1,000 New Zealand young adults studied to the age of 25. RESULTS Exposure to CSA and CPA was associated with increased risks of later mental dis...