نتایج جستجو برای: توالی kdel
تعداد نتایج: 7840 فیلتر نتایج به سال:
Molecular basis for KDEL-mediated retrieval of escaped ER-resident proteins – SWEET talking the COPs
A cisternal progression mode of intra-Golgi transport requires that Golgi resident proteins recycle by peri-Golgi vesicles, whereas the alternative model of vesicular transport predicts anterograde cargo proteins to be present in such vesicles. We have used quantitative immuno-EM on NRK cells to distinguish peri-Golgi vesicles from other vesicles in the Golgi region. We found significant levels...
To warrant the quality of the secretory proteome, stringent control systems operate at the endoplasmic reticulum (ER)-Golgi interface, preventing the release of nonnative products. Incompletely assembled oligomeric proteins that are deemed correctly folded must rely on additional quality control mechanisms dedicated to proper assembly. Here we unveil how ERp44 cycles between cisGolgi and ER in ...
Cholesterol homeostasis in animal cells is achieved by regulated cleavage of membrane-bound transcription factors, designated SREBPs. Proteolytic release of the active domains of SREBPs from membranes requires a sterol-sensing protein, SCAP, which forms a complex with SREBPs. In sterol-depleted cells, SCAP escorts SREBPs from ER to Golgi, where SREBPs are cleaved by Site-1 protease (S1P). Stero...
Microalgae systems have opened up new platforms for molecular farming in closed conditions. Recently, Dunaliella salina has been considered to be a suitable expression host for the production of recombinant proteins due to its significant advantages. It is a unicellular eukaryotic organism lacking cell wall and having post-translational processing for proteins which can grow in high salinity en...
Introduction Regulation of the secretory pathway by signalling ER export is regulated by signalling Modification of ER chaperones Modulation of COPII recruitment Lipid modification Signalling regulates the functional organisation of the Golgi complex PKD and PtdIns(4)P p38 PKA Signalling during directional cell migration Signalling from the secretory pathway A role for the ER in the compartment...
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