Objective: To investigate pathological alterations in morphologies of the portal vein, hepatic artery, and hepatic vein in patients with liver cirrhosis and portal hypertension (PHT), to study inducible nitric oxide synthase (iNOS) expression in the hepatic artery wall, and to explore roles of iNOS in pathogenetic mechanisms of portal hypertensive vasculopathy. Methods: Sections of the portal v...

BACKGROUND Congestive hepatomegaly might be the first sign for pulmonary hypertension. Apparent diffusion coefficient (ADC) value obtained with quantitative diffusion-weighted magnetic resonance imaging (DW-MRI) is affected by liver fibrosis and perfusion. We aimed to evaluate the diagnostic value of DW-MRI in cooperation with biochemical markers, ultrasonography (US) and echocardiography (TTE)...

INTRODUCTION Increasing evidence suggests that arterial hypertension (AHT) may begin in childhood and result in the premature development of cardiovascular disease. In view of this, we believed it would be important to investigate the early vascular changes related to early hypertension at the micro- and macrovascular levels both under normal circumstances and after cold-induced sympathetic sti...

The cytochrome P450 (P450)-dependent conversion of phenytoin (PHT) to p-hydroxy phenytoin (pHPPH), and tolbutamide (TLB) to 4-hydroxy tolbutamide (hydroxy-TLB), in human liver microsomes was studied in the presence of increasing concentrations (0-4%) of bovine serum albumin (BSA). Therefore, the free fraction (f(u)) of PHT and TLB varied. Whereas the f(u) of PHT (5 microM) decreased, an increas...

BACKGROUND Emerging evidence shows that anti-inflammatory strategies targeting inflammatory monocyte subset could reduce excessive inflammation and improve cardiovascular outcomes. Functional expression of voltage-gated sodium channels (VGSCs) have been demonstrated in monocytes and macrophages. We hypothesized that mononuclear phagocyte VGSCs are a target for monocyte/macrophage phenotypic swi...

The aim of this study was to evaluate the effects of hydrofluoric acid (HF) concentration and previous heat treatment (PHT) on the surface morphology and micro-shear bond strength (mSBS) of a lithium disilicate glass ceramic (EMX) to resin cement. One hundred four EMX specimens were randomly assigned to two groups (n=52) according to the HF concentration: 5% and 10%. A new random distribution w...

Portal hypertension (PHT) is a heterogeneous clinical entity which develops in patients with cirrhosis. It is responsible for many of the complications that occur in cirrhosis, including gastroesophageal varices, hepatorenal syndrome, ascites, hepatic encephalopathy and hypersplenism. There are three principal factors responsible for the development of PHT, namely (1) purely mechanical obstruct...

Background and Aims Portal hypertension (PHT) hepatocellular carcinoma (HCC) are major complication of cirrhosis which significantly contribute to morbidity mortality. In this review, we aim describe the consequences both angiogenesis inflammation in pathogenesis PHT HCC, but also difficulty propose adapted treatment when HCC coexist same patients. Methods Studies for review article were retrie...

Phenytoin (PHT), a drug in clinical use for over fifty years as an anticonvulsant, has heen reported to promote the healing of skin and soft tissue wounds, ulcers and second degree burns. We treated 19 patients with war-related missile wounds and 6 with chronic, non-healing (previously treated at least for.') months with antibiotics and betadine or acetic acid dressing) civilian ulcers wit...

Cirrhosis, the end stage of any chronic liver disease, can lead to portal hypertension (PHT), which can lead to fatal complications. Therefore, the prognosis and management of chronic liver diseases strongly depend on the severity of PHT. The best method to diagnose PHT is the direct measurement of portal pressure, and hepatic venous pressure gradient (HVPG) has been suggested as a reliable gol...