نتایج جستجو برای: تصویر irs

تعداد نتایج: 22679  

2010
Masao Kaneki Satoshi Furuhashi Masahiko Hirota Hiroshi Takamori Hideo Baba

ownload ic oxide (NO), which plays a role in the posttranslational modification of proteins, exhibits tumoricidal y. However, the mechanism remains largely unclear. We investigated whether the regulation of insulin resubstrate (IRS)-1 protein expression and insulin/insulin-like growth factor (IGF) signaling by NO is inin the proliferation and invasion of pancreatic cancer cells. NO donor inhibi...

Journal: :Heart 2005
A S Wierzbicki S Nishtar P J Lumb M Lambert-Hammill C N Turner M A Crook M S Marber J Gill

OBJECTIVE To assess the relation of the metabolic insulin resistance syndrome (M-IRS) with coronary heart disease (CHD) in Pakistani patients. SUBJECTS 200 patients with angiographic disease (CHD(+)) matched with 200 patients with chest pain without occlusive disease (CHD(-)). DESIGN Prospective case-control study. SETTING Tertiary referral cardiology unit in Pakistan. RESULTS M-IRS was...

Journal: :Hypertension 2004
Michiko Sugita Hiroki Sugita Masao Kaneki

Insulin resistance is associated with cardiovascular disease. Impaired insulin receptor substrate (IRS)-mediated signal transduction is a major contributor to insulin resistance. Recently, IRS-1 phosphorylation at serine 307 by stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) has been highlighted as a molecular event that causes insulin resistance. We investigated IRS-1-mediat...

Journal: :IEEE Transactions on Wireless Communications 2022

Channel estimation is a practical challenge for intelligent reflecting surface (IRS) aided wireless communication. As the number of IRS elements or IRS-aided users increases, channel training overhead becomes excessively high, which results in long delay and low throughput data transmission. To tackle this challenge, we propose paper new anchor-assisted approach, where two anchor nodes, namely ...

Journal: :Biochemical and biophysical research communications 2012
Hidehito Yoshihara Toshiaki Fukushima Fumihiko Hakuno Yasushi Saeki Keiji Tanaka Akihiro Ito Minoru Yoshida Shun-ichiro Iemura Tohru Natsume Tomoichiro Asano Kazuhiro Chida Leonard Girnita Shin-Ichiro Takahashi

Insulin receptor substrates (IRSs) play central roles in insulin/insulin-like growth factor (IGF) signaling and mediate a variety of their bioactivities. IRSs are tyrosine-phosphorylated by activated insulin receptor/IGF-I receptor tyrosine kinase in response to insulin/IGF, and are recognized by signaling molecules possessing the SH2 domain such as phosphatidylinositol 3-kinase (PI3K), leading...

Journal: :The Journal of biological chemistry 2003
Beth T Vander Kooi Ryan S Streeper Christina A Svitek James K Oeser David R Powell Richard M O'Brien

Glucose-6-phosphatase catalyzes the terminal step in the gluconeogenic and glycogenolytic pathways. In HepG2 cells, the maximum repression of basal glucose-6-phosphatase catalytic subunit (G6Pase) gene transcription by insulin requires two distinct promoter regions, designated A (located between -231 and -199) and B (located between -198 and -159), that together form an insulin response unit. R...

Journal: :The Biochemical journal 2005
Ingeborg Hers Jeremy M Tavaré

Serine and threonine phosphorylation of IRS-1 (insulin receptor substrate-1) has been reported to decrease its ability to be tyrosine-phosphorylated by the insulin receptor. Insulin itself may negatively regulate tyrosine phosphorylation of IRS-1 through a PI3K (phosphoinositide 3-kinase)-dependent feedback pathway. In the present study, we examined the regulation and role of IRS-1 serine phosp...

2003
Massimo Federici Antonio Petrone Ottavia Porzio Carla Bizzarri Davide Lauro Rossella D’Alfonso Ippolita Patera Marco Cappa Lorenza Nisticò Marco Baroni Giorgio Sesti Umberto di Mario Renato Lauro Raffaella Buzzetti

The Arg insulin receptor substrate-1 (IRS-1) variant has been hypothesized to play a role in pancreatic -cell stimulus-coupled insulin secretion and survival. We analyzed the relations between type 1 diabetes and the Arg IRS-1 variant. The frequency of the IRS-1 Arg variant was investigated in two independent sets of unrelated patients: a case-control study and a collection of type 1 diabetes s...

خسرو خواجه (مترجم)

 به ‏منظور دستیابى به روش دقیق تبدیل تصویربردارى PAN از تصویر فضایى به شئى فضایى یک مدل ریاضى طراحى شده است که در آن‏ براى تعیین توجیه خارجى تصاویر از حداقل یک نقظه کنترل زمینى (1) (GCP) استفاده مى‏ گردد. این مدل ریاضى در ابتدا براى تصاویر ماهواره اسپات تهیه شده بود که از معادلات همخطى جهت تهیه مدل مسیر ماهواره استفاده مى‏ گردد، در حالى که اختلاف ارتفاع ماهواره با زمان با استفاده از چند جمله ‏ا...

Journal: :The Iowa Review 2004

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