BACKGROUND Preoperative localization of parathyroid lesions is potentially beneficial in renal patients with hyperparathyroidism. The aim of this study was to determine the localizing value of hybrid single-photon emission computed tomography combined with low-dose x-ray computed tomography (SPECT/LDCT) compared with SPECT alone and whether the LDCT improved reader confidence. PATIENTS AND ME...

Quantitative measurement of myocardium perfusion is possible with single photon emission computed tomography (SPECT) using a semiconductor detector. However, accumulation of 99mTc-tetrofosmin in the liver may make it difficult to assess that accurately in the inferior myocardium. Our idea is to reduce the high accumulation in the liver by using dynamic SPECT imaging and a technique called time ...

BACKGROUND As model system, a solid-tumor patient-derived xenograft (PDX) model characterized by high peptide receptor expression and histological tissue homogeneity was used to study radiopeptide targeting. In this solid-tumor model, high tumor uptake of targeting peptides was expected. However, in vivo SPECT images showed substantial heterogeneous radioactivity accumulation despite homogenous...

An extension of the normalized mutual information similarity measurement was proposed to register cardiac PET/CT and SPECT images representing coronary artery disease in the heart. 23 PET/CT images obtained by a hybrid camera, and their corresponding SPECT were processed. The SPECT was registered to the PET/CT image pairs by a triple NMI based auto-registration. For validation and comparison an...

The goal of this study was to present a method for physiologic validation and show results for a comparison of the 4D-CT ventilation and SPECT ventilation or perfusion. A 4D-CT and a SPECT ventilation/perfusion (V/Q) (VSPECT and QSPECT) scans were acquired for a lung cancer patient. Two 4D-CT ventilation images were created using two metrics: Hounsfield unit (HU)-change (V4D-CT) and Jacobian de...

We have developed a new quantitative single-photon-emission computed tomography (SPECT) method that uses (113m)In-labeled albumin macroaggregates and Technegas ((99m)Tc) to estimate the distributions of regional ventilation and perfusion for the whole lung. The multiple inert-gas elimination technique (MIGET) and whole lung respiratory gas exchange were used as physiological evaluations of the ...

BACKGROUND Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to be more accurate than planar imaging in terms of lesion-based analysis. The aims of this study were to assess the feasibility and clinical usefulness of Ra-223 SPECT. The energy ...

There are many ways to perform noninvasive testing in patients with coronary artery disease (CAD), including myocar-dial perfusion imaging with single-photon emission computed tomography (SPECT), positron-emission tomography (PET), and coronary computed tomography angiography (CTA). Results from series of patients evaluated with single modalities have already been published by many researchers ...

Myocardial perfusion single photon emission computed tomography (SPECT) is widely used in assessing coronary artery disease (CAD) owing to its proven efficacy extensive clinical experience. Like other functional tests, myocardial SPECT recommended for the diagnosis of obstructive CAD, risk stratification assessment, and treatment decision making. Besides quantifying left ventricular volume, glo...

UNLABELLED Laparoscopic evaluation of sentinel nodes is useful for staging prostate cancer, but preoperative localization of deep abdominal sentinel nodes with planar lymphoscintigraphy is difficult. We evaluated the value of SPECT/CT for detecting and localizing sentinel nodes in prostate cancer. METHODS (99m)Tc-nanocolloid was injected peri- and intratumorally, guided by transrectal ultraso...