Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...

Introduction. The test for the induction of reverse gene mutations (Ames test, OECD* guideline No. 471) is one most popular methods assessing mutagenicity due to its ease execution and ability detect up 70-80% substances with carcinogenic activity. experimental protocol requires a minimum amount substance standard microbiological laboratory equipment. To obtain primary data, several days from s...

BACKGROUND Oryeong-san, a mixture of five herbal plants, is a well-known therapy for renal-associated diseases such as those manifesting edema, dysuria, and oliguria. METHODS In the present study, we investigatee the potential genotoxic effects of a water extract of Oryeong-san (ORSE) in three mutagenicity assays (an in vitro bacterial reverse mutation assay (Ames test) with Salmonella typhim...

Edward Balaban∗ NASA Ames Research Center, Moffett Field, California 94035 Abhinav Saxena SGT, Inc., NASA Ames Research Center, Moffett Field, California 94035 Sriram Narasimhan University ofCalifornia, SantaCruz,NASAAmes ResearchCenter,Moffett Field, California 94035 Indranil Roychoudhury SGT, Inc., NASA Ames Research Center, Moffett Field, California 94035 Michael Koopmans Tesla Motors, Palo ...

3-Nitro-1,2,4-triazol-5-one (NTO) is an energetic explosive proposed for use in weapon systems, to reduce the sensitivity of warheads. In order to develop toxicity data for safety assessment, we investigated the genotoxicity of NTO, using a battery of genotoxicity tests, which included the Ames test, Chinese Hamster Ovary (CHO) cell chromosome aberration test, L5178Y TK(+/-) mouse lymphoma muta...