In fever, as in normal thermoregulation, signals from the preoptic area drive both cutaneous vasoconstriction and thermogenesis by brown adipose tissue (BAT). Both of these responses are mediated by sympathetic nerves whose premotor neurons are located in the medullary raphé. EP3 receptors, key prostaglandin E2 (PGE2) receptors responsible for fever induction, are expressed in this same medulla...

Cytoplasmic dynein is a large molecular weight protein complex that functions as a microtubule-dependent, negative, end-directed "motor." Mutations in nudA, which encodes the heavy chain of cytoplasmic dynein, inhibit nuclear migration in Aspergillus nidulans. This paper describes the selection and characterization of extragenic suppressors of the nudA1 mutation preparatory to the identificatio...

Malpas, Simon C. What sets the long-term level of sympathetic nerve activity: is there a role for arterial baroreceptors? Am J Physiol Regul Integr Comp Physiol 286: R1–R12, 2004; 10.1152/ajpregu.00496.2003.—Much of our knowledge of the influence of the sympathetic nervous system on the control of blood pressure is built on experimental approaches that focus very much on time scales 24 h. Altho...

The thermoregulatory reflex effects of warming and cooling in the abdomen were investigated in 4 urethane-anesthetized Sprague-Dawley rats. Animals were shaved and surrounded by a water-perfused silastic jacket. Skin temperature under the jacket was recorded by thermocouples at 3 sites and brain temperature was monitored by a thermocouple inserted lateral to the hypothalamus. A heat exchanger m...

BACKGROUND It has been reported that sympathetic nerve activity (SNA) is associated with fibrinolysis, but the interaction between SNA and the fibrinolytic system with aging has not been elucidated in humans. The purpose of this study was to examine the effect of age-related SNA on the activity of plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (tPA) using muscle...

Although studies in anesthetized, sino-aortic denervated animals indicate that inhibition of central nitric oxide (NO) causes an excitatory influence on efferent sympathetic nerve activity (SNA) that is normally offset by baroreflex activation, studies in conscious animals have not provided clear-cut evidence for a sympathoexcitatory effect of N(omega)-nitro-l-arginine methyl ester (L-NAME) or ...

In recent years, the use of social network analysis (SNA) has received increased attention in R&D evaluation. While SNA provides insights into communication and knowledge flows, its efficacy in evaluation methodology remains unclear. As Rogers et al (2001) discuss, the applicability of SNA in the evaluation of R&D is marked by several shortcomings, such as the weakness of understanding the cont...

Social network analysis (SNA) is a widely studied research topics, which has been increasingly being applied for solving different kind of problems, including industrial manufacturing ones. This paper focuses on the application of SNA on an industrial plant layout problem. The study aims at analyzing the importance of using SNA techniques to analyze important relations between entities in a man...