hydroalcoholic extract of pycnocycla spinosa has spasmolytic effect in vitro and antidiarrhoeal action in vivo . the aim of this research was to separate fractions of total hydroalcoholic extract of p. spinosa guided by their spasmolytic activity. aerial parts of p. spinosa were extracted with ethanol. the concentrated extract was subjected to column chromatography and thin layer chromatography...

Chami, O., A. Megevand, T. Ott, F. Bazer, and C. O’Neill. Platelet-activating factor may act as an endogenous pulse generator for sheep of luteolytic PGF2a release. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E783–E792, 1999.— Pulsatile release of uterine prostaglandin F2a (PGF2a) induces luteolysis in ruminants. However, the mechanism(s) that initiates and maintains luteolysis has not been de...

The clinical observation that coronary artery disease is more common in men and postmenopausal women than in premenopausal women has suggested cardioprotective effects of female sex hormones including hormone-mediated coronary vasodilation. The purpose of this study was to investigate whether the sex hormone-induced coronary relaxation is caused by inhibition of Ca mobilization into coronary sm...

Vanillin (VA) and vanillyl alcohol (VAA), components of natural vanilla, and ethyl vanillin (EtVA; synthetic analog) are used as flavoring agents and/or as additives by the food, cosmetic, or pharmaceutic industries. VA, VAA, and EtVA possess antioxidant and anti-inflammatory properties, but their vascular effects have not been determined. Therefore, we compared in isolated porcine coronary and...

Abstract Background and Aims Recent studies demonstrate that klotho deficiency participate in various chronic kidney disease. However, it has not been fully assessed the influence of autoimmune diseases. On one hand, is known to binds transforming growth factor β (TGFβ) receptor antagonize its pathophysiological actions including renal fibrosis. other TGFβ required generate maintain regulatory ...