نتایج جستجو برای: اپی گالو کاتچین گالات egcg

تعداد نتایج: 4032  

2017
Liang Zeng Jingna Yan Liyong Luo Mengjun Ma Huiqun Zhu

We were employing nanotechnology to improve the targeting ability of (-)-Epigallocatechin-3-gallate (EGCG) towards MCF-7 cells, and two kinds of EGCG nanoparticles (FA-NPS-PEG and FA-PEG-NPS) were obtained, besides, their characteristics and effects on MCF-7 cells were studied. The results indicated that (i) both FA-NPS-PEG and FA-PEG-NPS have high stabilities; (ii) their particles sizes were 1...

2015
Alice Modernelli Valeria Naponelli Maria Giovanna Troglio Martina Bonacini Ileana Ramazzina Saverio Bettuzzi Federica Rizzi

The proteasome inhibitors Bortezomib (BZM) and MG132 trigger cancer cell death via induction of endoplasmic reticulum (ER) stress and unfolded protein response. Epigallocatechin gallate (EGCG), the most bioactive green tea polyphenol, is known to display strong anticancer properties as it inhibits proteasome activity and induces ER stress. We investigated whether combined delivery of a proteaso...

Journal: :Mediators of Inflammation 2008
Shinji Takai Rie Matsushima-Nishiwaki Seiji Adachi Hideo Natsume Chiho Minamitani Jun Mizutani Takanobu Otsuka Haruhiko Tokuda Osamu Kozawa

We previously showed that the mitogen-activated protein (MAP) kinase superfamily, p44/p42 MAP kinase, p38 MAP kinase, and stress-activated protein kinase (SAPK)/c-Jun N-terminal (JNK), positively plays a part in the platelet-derived growth factor-BB- (PDGF-BB-) stimulated synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in osteoblast-like MC3T3-E1 cells while Akt and p70 S6 ki...

Journal: :Pharmacological reports : PR 2010
Adikesavan Gokulakrishnan Abdul Rahman Liyakath Ali

The protective effect of epigallocatechin-3-gallate (EGCG) against cigarette smoke (CS) induced alterations in human erythrocyte was studied using an in vitro model. Hemolysis, carboxyhemoglobin, osmotic fragility, hemin, lipid peroxidation (LPO), protein thiol, protein carbonyl, glutathione, antioxidant enzymes, membrane bound ATPases and erythrocyte ghost protein were assessed to investigate ...

2016
Vojtech Mezera Rene Endlicher Otto Kucera Ondrej Sobotka Zdenek Drahota Zuzana Cervinkova

Epigallocatechin gallate (EGCG) is a green tea antioxidant with adverse effects on rat liver mitochondria and hepatocytes at high doses. Here, we assessed whether low doses of EGCG would protect these systems from damage induced by tert-butyl hydroperoxide (tBHP). Rat liver mitochondria or permeabilized rat hepatocytes were pretreated with EGCG and then exposed to tBHP. Oxygen consumption, mito...

Journal: :Neuropharmacology 2017
Lucia Machova Urdzikova Jiri Ruzicka Kristyna Karova Anna Kloudova Barbora Svobodova Anubhav Amin Jana Dubisova Meic Schmidt Sarka Kubinova Meena Jhanwar-Uniyal Pavla Jendelova

Spinal cord injury (SCI) is a debilitating condition which is characterized by an extended secondary injury due to the presence of inflammatory local milieu. Epigallocatechin gallate (EGCG) appears to possess strong neuroprotective properties. Here, we evaluated the beneficial effect of EGCG on recovery from SCI. Male Wistar rats were given either EGCG or saline directly to the injured spinal c...

Journal: :Clinical therapeutics 2012
Dina Halegoua-De Marzio Walter K Kraft Constantine Daskalakis Xie Ying Roy L Hawke Victor J Navarro

BACKGROUND Epigallocatechin-3-gallate (EGCG) has antiangiogenic, antioxidant, and antifibrotic properties that may have therapeutic potential for the treatment of cirrhosis induced by hepatitis C virus (HCV). However, cirrhosis might affect EGCG disposition and augment its reported dose-dependent hepatotoxic potential. OBJECTIVE The safety, tolerability, and disposition of a single oral dose ...

Journal: :Carcinogenesis 2005
Suparna Qanungo Madhusudan Das Subrata Haldar Aruna Basu

Polyphenols such as epigallocatechin-3-gallate (EGCG) from green tea extract can exert a growth-suppressive effect on human pancreatic cancer cells in vitro. In pursuit of our investigations to dissect the molecular mechanism of EGCG action on pancreatic cancer, we observed that the antiproliferative action of EGCG on pancreatic carcinoma is mediated through programmed cell death or apoptosis a...

Journal: :Molecular medicine 2004
Rajesh Aneja Paul W Hake Timothy J Burroughs Alvin G Denenberg Hector R Wong Basilia Zingarelli

Epigallocatechin-3-gallate (EGCG) is the most prominent catechin in green tea. EGCG has been shown to modulate numerous molecular targets in the setting of inflammation and cancer. These molecular targets have also been demonstrated to be important participants in reperfusion injury, hence this study examines the effects of EGCG in myocardial reperfusion injury. Male Wistar rats were subjected ...

Journal: :Cell transplantation 2009
Jung Yoon Bae Jun Kanamune Dong-Wook Han Kazuaki Matsumura Suong-Hyu Hyon

We investigated the hibernation effect of epigallocatechin-3-O-gallate (EGCG) on neonatal human tarsal fibroblasts (nHTFs) by analyzing the expression of cell cycle-related genes. EGCG application to culture media moderately inhibited the growth of nHTFs, and the removal of EGCG from culture media led to complete recovery of cell growth. EGCG resulted in a slight decrease in the cell population...

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