BACKGROUND Amyloid β (Aβ), a causative peptide of Alzheimer's disease, is generated by intracellular metabolism of amyloid β-protein precursor (APP). In general, mature APP (mAPP, N- and O-glycosylated form) is subject to successive cleavages by α- or β-, and γ-secretases in the late protein secretory pathway and/or at plasma membrane, while immature APP (imAPP, N-glycosylated form) locates in ...

INTRODUCTION Psoriatic arthritis (PsA) is underdiagnosed and has a substantial impact on quality of life, disability, and work productivity. The population-based Multinational Assessment of Psoriasis and Psoriatic Arthritis (MAPP) survey examined the impact of PsA on patients' activities of daily living and unmet treatment needs. METHODS This large-scale, random digit dialing, telephone surve...

This article investigates the development and evolution of hygroscopic stresses within flax/ Polypropylene + Maleic Anhydride grafted (PP MAPP) asymmetric biocomposites when exposed to various cycles that simulate a wide range outdoor applications with large Relative Humidity (RH) variation (from 11 50% RH, 50–99% 11–99% RH) cycling periods (1-week 24-hour between 50 around 90% RH). The transve...

A bstract We consider a dark sector containing pair of almost degenerate states coupled to the Standard Model through photon mediator. This set-up constitutes simple realization inelastic matter scenario. The heaviest state is long-lived, in limit small kinetic mixing among and hypercharge gauge boson, and/or mass splitting states. study prospects for detection this scenario at proposed LHC exp...

INTRODUCTION Studies using functional connectivity and network analyses based on magnetoencephalography (MEG) with source localization are rapidly emerging in neuroscientific literature. However, these analyses currently depend on the availability of costly and sometimes burdensome individual MR scans for co-registration. We evaluated the consistency of these measures when using a template MRI,...