Regulation of gene expression by transcription factors touches many aspects of eukaryotic biology, and its systematic, external control by organic molecules represents a challenge in chemistry. Here we report the design of a completely organic, nonpeptidic compound that mimics a transcription factor. The design takes advantage of the specific DNA-binding affinity of a hairpin polyamide molecule...

Amyotrophic lateral sclerosis (ALS) misdiagnosis has many broad implications for the patient and the neurologist. Potentially curative treatments exist for certain ALS mimic syndromes, but delay in starting these therapies may have an unfavorable effect on outcome. Hence, it is important to exclude similar conditions. In this review, we discuss some of the important mimics of ALS.

Neural network holds great promise to be the next generation computer for the sake of its strong capacity of massive parallel processing, good capability of discerning, compatibility with analog computing, self-learning ability, and so on. In this course project, I designed a basic biological function unit cell, which can mimic one basic biological conditioned reflex function in two versions: c...

agnostic challenge in the absence of pul− monary infection. Gastrointestinal TB can involve any part of the alimentary tract from the mouth to the anus, the dis− tal ileum being the most common site [1]. Lesions above and below this site are rare. A 72−year−old gentleman complaining of constipation, abdominal pain, and a 2− month history of loss of appetite and weight loss was referred to our g...

We establish a close quantitative analogy between the excitation and ionization process of highly excited one electron Rydberg states under microwave driving and charge transport across disordered 1D lattices. Our results open a new arena for Anderson localization – a disorder induced effect – in a large class of perfectly deterministic, decaying atomic systems. PACS. 32.80.Rm Multiphoton ioniz...