To investigate effects of altering troponin (Tn)C Ca(2+) binding properties on rate of skeletal muscle contraction, we generated three mutant TnCs with increased or decreased Ca(2+) sensitivities. Ca(2+) binding properties of the regulatory domain of TnC within the Tn complex were characterized by following the fluorescence of an IAANS probe attached onto the endogenous Cys(99) residue of TnC. ...

A Bayesian regularization-backpropagation neural network (BR-BPNN) model is employed to predict some aspects of the gecko spatula peeling, viz. variation maximum normal and tangential pull-off forces resultant force angle at detachment with peeling angle. K-fold cross validation used improve effectiveness model. The input data taken from finite element (FE) results. trained 75% FE dataset. rema...

In 1999, for (0≤k<∞), the concept of conic domain by defining k-uniform convex functions were introduced Kanas and Wisniowska then in 2000, they defined related k-starlike denoted k−UCV k−ST respectively. Motivated their studies, our work, we define class k-parabolic starlike functions, k−SHm,q, using quasi-subordination m-fold symmetric analytic making use Ωk. We determine coefficient bound...

We have studied the regulation of the K-Cl cotransporter KCC1 and its functional interaction with the Na-K-Cl cotransporter. K-Cl cotransporter activity was substantially activated in HEK-293 cells overexpressing KCC1 (KCC1-HEK) by hypotonic cell swelling, 50 mM external K, and pretreatment with N-ethylmaleimide (NEM). Bumetanide inhibited 86Rb efflux in KCC1-HEK cells after cell swelling [inhi...

This paper studies the maximum-clique independence problem and some variations of clique transversal such as {k}-clique, maximum-clique, minus clique, signed k-fold problems from algorithmic aspects for k-trees, suns, planar graphs, doubly chordal perfect total split line dually graphs. We give equations to compute numbers show that {k}-clique is polynomial-time solvable graphs whose equal thei...

Mevalonate kinase serine/threonine residues have been implicated in substrate binding and inherited metabolic disease. Alignment of >20 mevalonate kinase sequences indicates that Ser-145, Ser-146, Ser-201, and Thr-243 are the only invariant residues with alcohol side chains. These residues have been individually mutated to alanine. Structural integrity of the mutants has been demonstrated by bi...

In this paper, the integral binary quadratic forms for which the set of represented values is closed under k-fold products, for even positive integers k, will be characterized. This property will be seen to distinguish the elements of odd order in the form class group of a fixed discriminant. Further, it will be shown that this closure under k-fold products can always be expressed by a klinear ...