In Alzheimer's disease (AD), structural and functional brain network organization is disturbed. However, many of the present network analysis measures require a priori assumptions and methodological choices that influence outcomes and interpretations. Graph spectral analysis (GSA) is a more direct algebraic method that describes network properties, which might lead to more reliable results. In ...

In this paper, a hybrid gravitational search algorithm (GSA) and pattern search (PS) technique is proposed for load frequency control (LFC) of multi-area power system. Initially, various conventional error criterions are considered, the PI controller parameters for a two-area power system are optimized employing GSA and the effect of objective function on system performance is analyzed. Then GS...

doi: 10.1130/G32869.1 2012;40;407-410 Geology Naish, Benjamin S. Cramer, Yair Rosenthal, W. Richard Peltier and Sindia Sosdian Kenneth G. Miller, James D. Wright, James V. Browning, Andrew Kulpecz, Michelle Kominz, Tim R. deglaciation High tide of the warm Pliocene: Implications of global sea level for Antarctic Email alerting services articles cite this article to receive free e-mail alerts wh...

The heap leaching of minerals is one of the more commonly used processes in the mining industry. This process has been modeled by many authors. However, the validation, verification, and implementation of these models are difficult since there is uncertainty about the operating conditions and the leaching model parameters. This work uses the uncertainty quantification, based on uncertainty and ...

Complex optimization problems that cannot be solved using exhaustive search require efficient search metaheuristics to find optimal solutions. In practice, metaheuristics suffer from various types of search bias, the understanding of which is of crucial importance, as it directly pertinent to the problem of making the best possible selection of solvers. Two metrics are introduced in this study:...

In this study we analyzed the influence of region of interest (ROI) selection on the uptake ratio of the liver to the liver plus heart at 15 min (LHL15) during (99m)Tc-galactosyl human serum albumin (GSA) scintigraphy and determined the optimal ROI by evaluating the individual effects of different ROIs in the heart on LHL15. Twenty patients were randomly selected from those who had undergone (9...

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MOTIVATION Group-wise pattern analysis of genes, known as gene-set analysis (GSA), addresses the differential expression pattern of biologically pre-defined gene sets. GSA exhibits high statistical power and has revealed many novel biological processes associated with specific phenotypes. In most cases, however, GSA relies on the invalid assumption that the members of each gene set are sampled ...

Beyond the conviction that Major Depression can found its origin in genetics [1-3] a bio molecular mechanism could be hypothesized from what emerged from the studies on platelets fatty acid composition in human (normal and depressive subjects) which allowed classifying the depressive disorder [4] using an Artificial Neural Network (Self Organizing Map-SOM) [5], as mathematical tool, because of ...

Proline metabolism is an important pathway that has relevance in several cellular functions such as redox balance, apoptosis, and cell survival. Results from different groups have indicated that substrate channeling of proline metabolic intermediates may be a critical mechanism. One intermediate is pyrroline-5-carboxylate (P5C), which upon hydrolysis opens to glutamic semialdehyde (GSA). Recent...