One of the major cipher symmetric algorithms is AES. Its main feature is to use S-BOX step, which is the only non-linear part of this standard possessing fixed structure. During the previous studies, it was shown that AES standard security was increased by changing the design concepts of S-BOX and production of dynamic S-BOX. In this paper, a change of AES standard security is studied by produc...

BACKGROUND Due to methodological shortcomings the available post-registration data on the adverse events (AEs) occurring in interferon beta-1a (INFb-1a)-treated patients fail to adequately validate phase III data and only partially inform on safety in daily practice. We assessed AEs in relapsing remitting multiple sclerosis (RRMS) patients treated with intramuscular (IM) INFb-1a in daily practi...

BACKGROUND Up to now, costs attributable to adverse events (AEs) and preventable AEs in the Netherlands were unknown. We assessed the total direct medical costs associated with AEs and preventable AEs in Dutch hospitals to gain insight in opportunities for cost savings. METHODS Trained nurses and physicians retrospectively reviewed 7,926 patient records in 21 hospitals. Additional patient inf...

AIMS To characterize gastrointestinal adverse events (AEs) with different glucagon-like peptide-1 receptor agonists (GLP-1RAs). METHODS Two retrospective intention-to-treat analyses of 6-month patient-level data were conducted. Data from three studies comparing exenatide once weekly (n = 617) with exenatide twice daily (n = 606) were pooled, and one (DURATION-6) comparing exenatide once weekl...

INTRODUCTION The growing problem of antibacterial resistance resulted in an increased interest in fosfomycin, especially its parenteral formulation. We reviewed fosfomycin safety profile using the Food and Drug Administration Adverse Event (AE) Reporting System (FAERS) and published literature. METHODS We conducted a FAERS search and disproportionality analysis of all fosfomycin-associated AE...

Differential fault attack (DFA) is a distinctive methodology for acquiring the key to block ciphers, which comprises two distinct strategies: DFA on state and schedule. Given widespread adoption of Advanced Encryption Standard (AES), it has emerged as prominent target DFA. This paper presents an efficient AES, utilizing two−byte model that induces faults at with discontiguous rows. The experime...

OBJECTIVES To characterize risk factors for occurrence of adverse events (AEs) and treatment discontinuations due to AEs for improving safety and tolerability of treatment of postherpetic neuralgia (PHN). METHODS Patients with PHN (n=556) received 1800 mg once-daily gastroretentive gabapentin (G-GR) in 2 phase 3 and 1 phase 4 study. Safety assessments included the incidence and severity of AE...

The human Transducin-like Enhancer of Split (TLE) and mouse homologue, Groucho gene-related protein (GRG), represent a family of conserved non-DNA binding transcriptional modulatory proteins divided into two subgroups based upon size. The long TLE/GRGs consist of four pentadomain proteins that are dedicated co-repressors for multiple transcription factors (TF). The second TLE/GRG subgroup is co...

One difficulty in the cryptanalysis of the Advanced Encryption Standard AES is the tension between operations in the two fields GF (2) and GF (2). This paper outlines a new approach that avoids this conflict. We define a new block cipher, the BES, that uses only simple algebraic operations in GF (2). Yet the AES can be regarded as being identical to the BES with a restricted message space and k...