The antigens reacting with cold-aggluantigen and antibody were not able to tinin antibodies and present in the red react at 37#{176}Cwhen the antigen was cell membranes of human red cells were present in the intact cell, after solubilizafound in the water-phase when the tion, antigen and antibody reacted washed membranes were extracted with equally well at 37#{176}Cand at 0#{176}C. The n-butano...

P ATIENTS \VITH UREMIA frequently have both prolonged bleeding times,11#{176} suggesting poor platelet plug formation, and impaired prothrombin consumption,1’2’46’#{176}14 ascribed to defective platelet factor 3 activalion. Considerable evidence points to the presence of a qualitative platelet defect in uremia, since such abnormalities cannot be attributed to the mild thrombocytopenia occasiona...

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INTRODUCTION T HE DIEGO ( Di’ ) blood factor, first described by Levine,1’27 and Layrisse2’3 has been extensively studied.22#{176} It is serologically distinct from other known blood factors,3 does not appear to be linked to any of them1 and may represent a separate blood group system.”12 The factor is of anthropological interest because of its presence in most North and South American Indian t...

This report describes a black family in which two distinct structural defects of alpha spectrin were inherited singly and in combination. The propositus, who has a poikilocytic hemolytic anemia that shares many of the features of hereditary pyropoikilocytosis (HPP) or homozygous elliptocytosis. is a compound heterozygote for both the spectrin alpha”5 and spectrin alpha’ #{176} defects as demons...

By H. S. WINCHELL, MYRON POLLYCOVE, W. D. LOUGHMAN AND J. H. LAWRENCE R ELATIVELY selective beta irradiation of the lymphatic system in the dog has been achieved with internally administered Yttrium90 chelated with diethylene triamine penta-acetic acid ( Y90-DTPA) . Intravenous injection of Y#{176}#{176}-DTPA followed by continuous intravenous infusion of the animal’s own urine containing the e...

BACKGROUND Cysteinyl-leukotrienes are mediators of inflammatory responses in bronchial asthma. We studied the genes encoding the enzymes involved in their synthesis to identify risk factors for asthma. The promoter polymorphisms LTC4S -444 A/C, ALOX5 -176/-147, and ALOX5AP -169/-146 have been reported to be associated with bronchial asthma. METHODS We analyzed the effects of LTC4S -444 A/C, A...

By D. L. DUNGwORTH, NI. GOLDMAN, J. W. SWITZER AND D. H. MCKELVIE T HE TERM “MYELOPROLIFERATIVE DISORDER” was introduced by 2 to embrace a complex array of diseases characterized by irreversible proliferation of one to several of the bone marrow cell lines, and includes such conditions as granulocytic leukemia, myelofibrosis with myeloid metaplasia, polycythemia vera and erythremic myelosis. Th...