Weber, Jean-Michel, and Deena S. Shanghavi. Regulation of glucose production in rainbow trout: role of epinephrine in vivo and in isolated hepatocytes. Am J Physiol Regulatory Integrative Comp Physiol 278: R956–R963, 2000.— The rate of hepatic glucose production (Ra glucose) of rainbow trout (Oncorhynchus mykiss) was measured in vivo by continuous infusion of [6-3H]glucose and in vitro on isola...

Chupreta, Sergey, Ming Du, Andrea Todisco, and Juanita L. Merchant. EGF stimulates gastrin promoter through activation of Sp1 kinase activity. Am J Physiol Cell Physiol 278: C697–C708, 2000.—Epidermal growth factor (EGF) receptor activation stimulates gastrin gene expression through a GC-rich element called gastrin EGF response element (gERE). This element is bound by Sp1 family members and is ...

Busk, Morten, Frank B. Jensen, and Tobias Wang. Effects of feeding on metabolism, gas transport, and acid-base balance in the bullfrog Rana catesbeiana. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R185–R195, 2000.—Massive feeding in ectothermic vertebrates causes changes in metabolism and acid-base and respiratory parameters. Most investigations have focused on only one aspect of...

TAMAE YODA,1 LARRY I. CRAWSHAW,2 KYOKO YOSHIDA,1 LIU SU,1 TAKAYOSHI HOSONO,2 OSAMU SHIDO,3 SOTARO SAKURADA,3 YUTAKA FUKUDA,1 AND KAZUYUKI KANOSUE2 1Department of Physiology and Biosignalling, Graduate School of Medicine, Osaka University, Osaka; 2Department of Physiology, School of Allied Health Sciences, Osaka University Faculty of Medicine, Osaka 565-0871; and 3Department of Physiology, Schoo...

Polychlorinated biphenyls (PCBs) and the structurally related polybrominated diphenyl ethers (PBDEs) are abundant persistent organic pollutants that exert several comparable neurotoxic effects. Importantly, hydroxylated metabolites of PCBs and PBDEs have an increased neurotoxic potency. Recently, we demonstrated that PCBs can act as (partial) agonist on GABAA neurotransmitter receptors, with PC...

Polychlorinated biphenyls (PCBs) and the structurally related polybrominated diphenyl ethers (PBDEs) are abundant persistent organic pollutants that exert several comparable neurotoxic effects. Importantly, hydroxylated metabolites of PCBs and PBDEs have an increased neurotoxic potency. Recently, we demonstrated that PCBs can act as (partial) agonist on GABA(A) neurotransmitter receptors, with ...

MacLean, David A., Virginia A. Imadojemu, and Lawrence I. Sinoway. Interstitial pH, K1, lactate, and phosphate determined with MSNA during exercise in humans. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R563–R571, 2000.—The purpose of the present study was to use the microdialysis technique to simultaneously measure the interstitial concentrations of several putative stimulators ...

Zhang, Rong, Julie H. Zuckerman, and Benjamin D. Levine. Spontaneous fluctuations in cerebral blood flow: insights from extended-duration recordings in humans. Am J Physiol Heart Circ Physiol 278: H1848–H1855, 2000.—To determine the dependence of cerebral blood flow (CBF) on arterial pressure over prolonged time periods, we measured beat-to-beat changes in mean CBF velocity in the middle cerebr...

Mennitt, Patricia A., Gustavo Frindt, Randi B. Silver, and Lawrence G. Palmer. Potassium restriction downregulates ROMK expression in rat kidney. Am J Physiol Renal Physiol 278: F916–F924, 2000.—The ROMK family of proteins has biophysical properties and distribution within the kidney similar to those of secretory potassium channels of the distal nephron. To study the regulation of ROMK during v...

Juel, Carsten, Jens Jung Nielsen, and Jens Bangsbo. Exercise-induced translocation of Na1-K1 pump subunits to the plasma membrane in human skeletal muscle. Am J Physiol Regulatory Integrative Comp Physiol 278: R1107– R1110, 2000.—Six human subjects performed one-legged knee extensor exercise (90 6 4 W) until fatigue (exercise time 4.6 6 0.8 min). Needle biopsies were obtained from vastus latera...