نتایج جستجو برای: آنزیم na k atpase

تعداد نتایج: 652131  

2010
Daiane S. Alves Glen A. Farr Patricia Seo-Mayer Michael J. Caplan

The Na(+),K(+)-ATPase is the major active transport protein found in the plasma membranes of most epithelial cell types. The regulation of Na(+),K(+)-ATPase activity involves a variety of mechanisms, including regulated endocytosis and recycling. Our efforts to identify novel Na(+),K(+)-ATPase binding partners revealed a direct association between the Na(+),K(+)-ATPase and AS160, a Rab-GTPase-a...

Journal: :Journal of cell science 2009
Emilia Lecuona Alexander Minin Humberto E Trejo Jiwang Chen Alejandro P Comellas Haiying Sun Doris Grillo Oxana E Nekrasova Lynn C Welch Igal Szleifer Vladimir I Gelfand Jacob I Sznajder

Stimulation of Na(+)/K(+)-ATPase activity in alveolar epithelial cells by cAMP involves its recruitment from intracellular compartments to the plasma membrane. Here, we studied the role of the actin molecular motor myosin-V in this process. We provide evidence that, in alveolar epithelial cells, cAMP promotes Na(+)/K(+)-ATPase recruitment to the plasma membrane by increasing the average speed o...

Journal: :Journal of cell science 2012
Charitha Galva Pablo Artigas Craig Gatto

Na(+)/K(+)-ATPase, an integral membrane protein, has been studied for over a half century with respect to its transporter function in the plasma membrane, where it expels three Na(+) ions from the cell in exchange for two K(+) ions. In this study, we demonstrate a functioning Na(+)/K(+)-ATPase within HEK293 cell nuclei. This subcellular localization was confirmed by western blotting, ouabain-se...

Journal: :Revista brasileira de psiquiatria 2014
Gislaine T Rezin Giselli Scaini Cinara L Gonçalves Gabriela K Ferreira Mariane R Cardoso Andréa G K Ferreira Maira J Cunha Felipe Schmitz Roger B Varela João Quevedo Angela T S Wyse Emilio L Streck

OBJECTIVES Fenproporex is an amphetamine-based anorectic which is rapidly converted into amphetamine in vivo. Na+, K+-ATPase is a membrane-bound enzyme necessary to maintain neuronal excitability. Considering that the effects of fenproporex on brain metabolism are poorly known and that Na+, K+-ATPase is essential for normal brain function, this study sought to evaluate the effect of this drug o...

2004
Riad Efendiev Rafael T. Krmar Goichi Ogimoto Jean Zwiller Grazia Tripodi Adrian I. Katz Giuseppe Bianchi Carlos H. Pedemonte Alejandro M. Bertorello

-Adducin polymorphism in humans is associated with abnormal renal sodium handling and high blood pressure. The mechanisms by which mutations in adducin affect the renal set point for sodium excretion are not known. Decreases in Na ,K -ATPase activity attributable to endocytosis of active units in renal tubule cells by dopamine regulates sodium excretion during high-salt diet. Milan rats carryin...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1990
M A Reuben L S Lasater G Sachs

The catalytic subunit of the H+/K(+)-transporting ATPase (EC 3.6.1.3) has 62% identity to the alpha, or catalytic subunit, of the Na+/K(+)-transporting ATPase (EC 3.6.1.37); however, a homologous beta subunit was unknown until recently. Removal of the carbohydrate from purified hog H+/K(+)ATPase vesicles reveals a 35-kDa peptide that, when fragmented with protease V8, gives sequences homologous...

Journal: :Journal of the American Society of Nephrology : JASN 2004
Manlio Vinciguerra Serge Arnaudeau David Mordasini Martine Rousselot Marcelle Bens Alain Vandewalle Pierre-Yves Martin Udo Hasler Eric Feraille

In the renal collecting duct (CD), the Na,K-ATPase, which provides the driving force for Na+ absorption, is under tight multifactorial control. Because CD cells are physiologically exposed to variations of interstitial and tubular fluid osmolarities, the effects of extracellular anisotonicity on Na,K-ATPase cell surface expression were studied. Results show that hypotonic conditions increased, ...

Journal: :American journal of physiology. Renal physiology 2006
Käthi Geering

FXYD proteins belong to a family of small-membrane proteins. Recent experimental evidence suggests that at least five of the seven members of this family, FXYD1 (phospholemman), FXYD2 (gamma-subunit of Na-K-ATPase), FXYD3 (Mat-8), FXYD4 (CHIF), and FXYD7, are auxiliary subunits of Na-K-ATPase and regulate Na-K-ATPase activity in a tissue- and isoform-specific way. These results highlight the co...

2010
Kaori Saito Nobuhiro Nakamura Yusuke Ito Kazuyuki Hoshijima Masahiro Esaki Boqiang Zhao Shigehisa Hirose

FXYD proteins, small single-transmembrane proteins, have been proposed to be auxiliary regulatory subunits of Na(+)-K(+)-ATPase and have recently been implied in ion osmoregulation of teleost fish. In freshwater (FW) fish, numerous ions are actively taken up through mitochondrion-rich cells (MRCs) of the gill and skin epithelia, using the Na(+) electrochemical gradient generated by Na(+)-K(+)-A...

B. B. Kaliwal, R. L. Ksheerasagar

Carbosulfan (2,3-dihydro-2,2dimethyl-7-benzofuronyl [(dibutyl amino) thio] methyl] a carbamate insecticide and acaricide was administered orally at an effective dose of 48 mg/kg/day to albino mice for 5, 10, 20 and 30 days .Control mice received similar quantities of olive oil. Daily body weights were recorded and mice were sacrificed after 24 hours after the terminal exposure. The histologic e...

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