نتایج جستجو برای: آنتی tumor necrosis factor tnf

تعداد نتایج: 1254222  

Journal: :The Journal of clinical investigation 1993
P Costelli N Carbó L Tessitore G J Bagby F J Lopez-Soriano J M Argilés F M Baccino

Rats bearing the Yoshida AH-130 ascites hepatoma showed enhanced fractional rates of protein degradation in gastrocnemius muscle, heart, and liver, while fractional synthesis rates were similar to those in non-tumor bearing rats. This hypercatabolic pattern was associated with marked perturbations of the hormonal homeostasis and presence of tumor necrosis factor in the circulation. The daily ad...

Journal: :Circulation research 2013
Masatsugu Hori Osamu Yamaguchi

Although detrimental effects of tumor necrosis factor-α (TNF-α) have been reported in failing myocardium, clinical trials using TNF-α antagonists did not show the benefit of TNF-α inhibition in patients with chronic heart failure (CHF). The double-edged effects of TNF-α/Toll-like receptors (TLRs)-related proinflammatory cytokines and downstream signal transduction, nuclear factor (NF)-κB activa...

Journal: :Turkish Journal of Veterinary & Animal Sciences 2023

This study investigates the effects of simvastatin (SMV) on human umbilical vein endothelial cells (HUVECs) inflamed by tumor necrosis factor-alpha (TNF-a). Cells were treated with (5 μM, 10 and 50 μM) with/without TNF (20 ng/mL). The proliferation examined, its cytotoxic effect was determined lactate dehydrogenase (LDH) assays. Metalloproteinase expression (MMP-2 MMP-9) levels SMV at different...

2004
ELISABETH MOREAU

We have studied the interference of soluble tumor necrosis factor-a receptor p55 (sTNF-R55) on the quantification of tumor necrosis factor-a (TNF-a) in three immunoassays: the commercially available enzyme amplified-sensitivity immunoassay (EASLA) of Medgenix and the ELISA of Boehringer Mannheim, and an assay based on electrochemiluminescence (ECL) technology. TNF-a measurements by EASLA and EL...

Journal: :Journal of the American College of Cardiology 2000
M Satoh M Nakamura H Satoh H Saitoh I Segawa K Hiramori

OBJECTIVES We determined whether tumor necrosis factor-alpha-converting enzyme (TACE) is expressed with tumor necrosis factor-alpha (TNF-alpha) in myocarditis. BACKGROUND Tumor necrosis factor-alpha-converting enzyme, which has recently been identified as belonging to the family of metalloproteinase disintegrin proteins, is responsible for the conversion of TNF-alpha precursor to its mature f...

Journal: :Turkish journal of veterinary research 2022

Objective: This study aimed to monitor oxidative stress parameters including total antioxidant status (TAS) and oxidant (TOS), tumor necrosis factor-alpha (TNF-α) level during the healing process in hair goats with metritis. 
 Materials Methods: was carried out on a of 25 metritis (n=10; Group 1) healthy (n=15; 2). The beginning accepted as day 0. In both 1 2, blood samples were collected ...

F. M. Guerra-Infante M. J. de Haro-Cruz M. López-Hurtado, M. R. Escobedo-Guerra

The armadillo could be considered as an experimental model for leprosy studies. Mycobacterium leprae main host cells are macrophages and Schwann cells. However, endocytosis and germicidal activities of armadillo macrophages and monocytes have not yet been evaluated. The aim of this research was to evaluate endocytosis and NBT-reduction activities of monocyte-derived macrophages (MDM) and monocy...

Objective(s): It is generally believed that the inflammatory response in bone marrow mesenchymal stem cells (BMSCs) transplantation leads to poor survival and unsatisfactory effects, and is mainly mediated by cytokines, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α). In this study, we explored the mechanisms underlying the TNF-α-induced inflammatory ...

Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine which plays crucial roles in pathogenesis of inflammatory diseases. The current study aimed to investigate the binding abilities of I44 and I49 domain antibodies to TNF-α. The dAbs were expressed in bacterial expression system and purified by affinity chromatography using Ni-sepharose column. The expression and purity of the protei...

Journal: :The Journal of pharmacology and experimental therapeutics 1999
S Tsunoda T Ishikawa Y Yamamoto H Kamada K Koizumi J Matsui Y Tsutsumi T Hirano T Mayumi

We attempted to develop a novel method for the chemical modification of cytokines with synthetic polymers to increase in vivo therapeutic efficacy. A pH-reversible amino-protective reagent, dimethylmaleic anhydride (DMMAn), was used for polymer conjugation of tumor necrosis factor-alpha (TNF-alpha) with polyethylene glycol (PEG). The novel PEGylated TNF-alpha, PEG-TNF-alpha(+), which was pretre...

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