Background • Therapies for rare diseases have ignited industry-wide debates concerning patient access, pricing and efficacy. Urea cycle disorders (UCD), a genetic rare disease, is a target for enzyme replacement therapies, yet UCD epidemiology data are scarce. For payers and pharmaceutical companies to accurately forecast patient cost of care, accurate patient population estimates are a necessi...

We present initial results from a survey of the Orion A and B molecular clouds made with the InfraRed Array Camera (IRAC) onboard the Spitzer Space Telescope. This survey encompasses a total of 5.6 square degrees with the sensitivity to detect objects below the hydrogen burning limit at an age of 1 Myr. These observations cover a number of known star forming regions, from the massive star formi...

We re-examine the nature of NGC 2024 IRS2 in light of the recent discovery of the late O-type star, IRS2b, located 5′′ from IRS2. Using L-band spectroscopy, we set a lower limit of AV = 27.0 mag on the visual extinction towards IRS2. Arguments based on the nature of the circumstellar material, favor an AV of 31.5 mag. IRS2 is associated with the UCH region G206.543–16.347 and the infrared sou...

Fatigue failure characteristics of friction stir welds in 13mm gauge 2024-T351 plate have been assessed. Failure occurred from either the weld region (nugget/flow arm) or from the material immediately surrounding the weld. Fatigue failure from the surrounding material was essentially conventional, initiating from large S-phase intermetallic particles and growing in a macroscopic mode I manner. ...

We used the Submillimeter Array (SMA) to observe the thermal polarized dust emission from the protostellar source NGC 2024 FIR 5. The polarized emission outlines a partial hourglass morphology for the plane-ofsky component of the core magnetic field. Our data are consistent with previous BIMA maps, and the overall magnetic field geometries obtained with both instruments are similar. We resolve ...

2024 T3 is one of aluminium alloys which are widely used in the aircraft structures. Anodizing of alluminium alloy in tartaric-sulphuric acid (TSA) electrolyte is developed to obtain more environmentally-friendly process and to produce anodize layer with better corrosion resistance. In this research work, the influences of anodizing parameters of Al 2024 T3 in TSA on the thickness, weight and c...

-This study investigates heat generation in metals during plastic deformation. Experiments were designedto measure the partition of plastic work into heat and stored energy during dynamic deformations under adiabatic conditions. A servohydraulic load frame was used to measure mechanical properties at lower strain rates, 10 -3 s -1 to 1 s -1. A Kolsky pressure bar was used to determine mechanica...

The viscoelastic response of pure Al and 7075 (AlZnMg) and 2024 (AlCuMg) alloys, obtained with a dynamic-mechanical analyzer (DMA), is studied. The purpose is to identify relationships between the viscoelasticity and fatigue response of these materials, of great interest for structural applications, in view of their mutual dependence on intrinsic microstructural effects associated with internal...