نتایج جستجو برای: آشکارسازهای تکثیرکننده الکترون گازی gem
تعداد نتایج: 12652 فیلتر نتایج به سال:
A gemcitabine (GEM)-resistant human pancreatic cancer cell line (PANC-1RG7) was established in vitro by gradually increasing GEM concentrations and cloning cell cultures to develop a cellular model of acquired drug resistance studies. We found that PANC-1RG7 cells exhibited significantly different morphological characteristics from parental cells. PANC-1RG7 cells grew slowly (p<0.05), yet the c...
Snow surface-to-air exchange of gaseous elemental mercury (GEM) was measured using a modified Teflon fluorinated ethylene propylene (FEP) dynamic flux chamber (DFC) in a remote, open site in Potsdam, New York. Sampling was conducted during the winter months of 2011. The inlet and outlet of the DFC were coupled with a Tekran Model 2537A mercury (Hg) vapor analyzer using a Tekran Model 1110 two p...
CD1 proteins present microbial lipids to T cells. Germline-encoded mycolyl lipid-reactive (GEM) T cells with conserved αβ T cell receptors (TCRs) recognize CD1b presenting mycobacterial mycolates. As the molecular basis underpinning TCR recognition of CD1b remains unknown, here we determine the structure of a GEM TCR bound to CD1b presenting glucose-6-O-monomycolate (GMM). The GEM TCR docks cen...
The gon-2 gene of Caenorhabditis elegans encodes a TRPM cation channel required for gonadal cell divisions. In this article, we demonstrate that the gonadogenesis defects of gon-2 loss-of-function mutants (including a null allele) can be suppressed by gain-of-function mutations in the gem-1 (gon-2 extragenic modifier) locus. gem-1 encodes a multipass transmembrane protein that is similar to SLC...
In this paper, logical masking capability of commonly used logic gates such as NOT, AND/NAND, OR/NOR, and XOR/XNOR, when subject to single/multiple input faults, are analyzed from a mathematical perspective. A new metric, called Gate Error Metric (GEM) is proposed to study the extent of output error in these gates when subject to potential input fault occurrences, where less value of GEM implie...
Two gem-difluoromethylenated nucleoside moieties of liposidomycins, 3 and 4, were designed and synthesized. Compound 3 was assembled from lactol 5 and gem-difluoromethylenated nucleoside 6. In the synthesis of target molecule 4, the coupling of the trichloroacetimidate derivative of gem-difluoromethylenated furanose 7 with nucleoside 8 in the presence of TMSOTf gave the unexpected compound 16 w...
گرافن لایه دو بعدی از اتم های کربن با پیوند sp2 در شبکه لانه زنبوری می باشد. پیکربندی منحصر بفرد اتم های کربن منجر به یک رابطه ی پراکندگی جدید در حوالی انرژی دیراک می شود. در حوالی نقطه دیراک طیف دو بعدی، خطی است و در نتیجه الکترون ها با سرعت ثابت (100 بربار بیشتر از سیلیکان) در حرکت هستند. بسیاری از ویژگی های جذاب گرافن ناشی از این رابطه پراکندگی است که ناشی از فرمیون های نسبی بی جرم می باشد. ...
دستگاه پلاسمای کانونی قابلیت تولید الکترون، یون، نوترون و پرتو ایکس نرم و سخت را در گسترهای از طول موجها و انرژیها دارد. در این پروژه برای طیفنمایی پرتوهای ایکس نرم گسیلیده از دستگاه پلاسمای کانونی دانشگاه صنعتی شریف یک طیفسنج طراحی و ساخته شد. طرح کلی این طیفسنج طرح جوهان است که در آن از یک بلور خمیدهی استوانهای استفاده شده است.نحوهی عملکرد این طیفسنج براساس قانون براگ بوده و دلیل اس...
Poly (ADP-ribose) polymerase-1 (PARP-1) and autophagy play increasingly important roles in DNA damage repair and cell death. Gemcitabine (GEM) remains the first-line chemotherapeutic drug for pancreatic cancer (PC). However, little is known about the relationship between PARP-1 expression and autophagy in response to GEM. Here we demonstrate that GEM induces DNA-damage response and degradation ...
This study was carried out to investigate an effective method for the co-delivery of Gemcitabine (GEM) and paclitaxel (PTX) into tumor cells. GEM and PTX were modified with functional (+)-a-tocopherol (VE) to obtain similar water solubility. Folic acid-poly(ethylene glycol)–(+)-a-tocopherol (FA–PEG–VE) was designed to co-encapsulate the modified GEM and PTX. Methoxy poly(ethylene glycol)–poly(l...
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