نتایج جستجو برای: آزمون warm tail immersion
تعداد نتایج: 213901 فیلتر نتایج به سال:
In addition to its central actions, morphine has important peripheral effects. To examine peripheral analgesic mechanisms, we developed a topical opioid paradigm in which the tail was immersed in a dimethyl sulfoxide (DMSO) solution containing various drugs. Alone, DMSO was inactive in the tail-flick assay in mice. DMSO solutions containing morphine and peptides such as [D-Ala2,MePhe4, Gly(ol)5...
Water immersion is widely used in physiotherapy and might relieve pain, probably by activating several distinct somatosensory modalities, including tactile, pressure, and thermal sensations. However, the endogenous mechanisms behind this effect remain poorly understood. This study examined whether warm water immersion therapy (WWIT) produces an antiallodynic effect in a model of localized infla...
BACKGROUND Regular physical activity and exercise are well-known cardiovascular protective factors. Many elderly patients with heart failure find it difficult to exercise on land, and hydrotherapy (training in warm water) could be a more appropriate form of exercise for such patients. However, concerns have been raised about its safety.The aim of this study was to investigate, with echocardiogr...
Background and Objective: Hyperalgesia is one of the signs of diabetes mellitus that affects the life quality of patients. Nigella sativa-derived thymoquinone exhibits antidiabetic and anti-inflammatory effects. This study was designed to investigate the antinociceptive effect of thymoquinone (TQ) in streptozotocin-diabetic rats. Materials and Methods: Rats were divided into control,...
Bursting pacemaker neurons of Tritonia and Aplysia were studied in voltage-clamp experiments to determine the ionic requirements of the slow outward tail current. This current is important for terminating bursts and hyperpolarizing the neuron during the interval between bursts and therefore contributes to the timing of pacemaker activity. A method for rapid extracellular perfusion of the neuron...
ترکیبات مسکن یا هوشبر ممکن است باعث نرودجنره شدن آپوپتوتیک مغز در حال رشد جوندگان نابالغ شود، که شامل کتامین(آنتاگونیستnmda) و آگونیست گیرنده های gabaa (بنزودیازپین ها) و یا بلوکر های کانالهای سدیمی می باشند. هدف از این تحقیق بررسی اثر تجویز مکرر دوز هوشبر کتامین در دوران نوزادی و مطالعه ی تشنج پذیری بر تغییرات مغز و میزان پاسخ به درد در دوران بلوغ بوده است. موش های صحرایی نر نوزاد (در 2 گروه ک...
Experimental infection of fish for vaccine efficacy studies is associated with several limitations. Administration of live bacteria with the purpose of causing disease in fish can be performed by co-habitation, immersion or injection. We have developed a new Aeromonas salmonicida challenge method for rainbow trout and have applied it for evaluation of furunculosis vaccine efficacy. The method r...
OBJECTIVE To evaluate the antinociceptive activity of the methanol extract of Ricinus communis leaves (MRCL). METHODS Antinociceptive activity was evaluated using acetic acid induced writhing test, formalin induced paw licking and tail immersion method in mice at doses of 100, 125 and 150 mg/kg bw. RESULTS The results indicated that MRCL exhibited considerable antinociceptive activity again...
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