In-situ testing techniques have proven to be successful in improving the speed and reliability of geotechnical investigations. One of the most common in-situ methods in engineering geology and site investigation is Cone Penetration Test (CPT), which is mainly used for characterization of soils, as it is a robust, simple, fast, reliable and economic test that can provide continuous soundings of ...

We study the space-time CPT properties of string theories formulated in a flat Minkowski background of even dimension. We define CPT as a world-sheet transformation acting on the vertex operators and we prove the CPT invariance of the string S-matrix elements. Some related issues, including the connection between spin and statistics of physical string states, are also considered. † Supported by...

Irinotecan (CPT-11) is an anticancer drug that occasionally produces acute cholinergic side effects. Preliminary findings suggest that these are mediated through the inhibition of acetylcholinesterase (AChE). In this study, the inhibition of various AChEs by CPT-11 was studied. The lactone form of CPT-11 resulted in apparent noncompetitive inhibition of electric eel and both human recombinant a...

We have studied apoptosis of gastrointestinal epithelial cells by examining the receptor-mediated and DNA damage-induced pathways using TNF-α and camptothecin (CPT), respectively. TNF-α requires inhibition of antiapoptotic protein synthesis by cycloheximide (CHX). CHX also results in high levels of active JNK, which are necessary for TNF-induced apoptosis. While CPT induces apoptosis, the incre...

Background: We aimed to determine the expression of two neuropeptides, neuropeptide Y (NPY) and vasoactive intestine peptide (VIP), in the pathological tissues of congenital pseudarthrosis of the tibia (CPT) patients for understanding the etiology and pathogenesis of CPT. Methods: Periosteum and bone specimens from 20 CPT patients were studied, in comparison to 20 normal periosteum and bone tis...

PURPOSE Camptothecin (CPT) has potent broad-spectrum antitumor activity by inhibiting type I DNA topoisomerase (DNA topo I). It has not been used clinically because it is water-insoluble and highly toxic. As a result, irinotecan (CPT-11), a water-soluble analogue of CPT, has been developed and used as salvage chemotherapy in patients with relapsed/refractory lymphoma, but with only modest activ...

BACKGROUND Limited data exist on cotrimoxazole prophylactic treatment (CPT) in pregnant women, including protection against malaria versus standard intermittent preventive therapy with sulfadoxine-pyrimethamine (IPTp). METHODS Using observational data we examined the effect of CPT in HIV-infected pregnant women on malaria during pregnancy, low birth weight and preterm birth using proportional...

Liposome formulations of camptothecins have been actively pursued because of the potential for significant pharmacologic advantages from successful drug delivery of this important class of anticancer drugs. We describe nanoliposomal CPT-11, a novel nanoparticle/liposome construct containing CPT-11 (irinotecan) with unprecedented drug loading efficiency and in vivo drug retention. Using a modifi...

The regulation of hepatic mitochondrial carnitine palmitoyltransferase-I (CPT-I) was studied in rats during starvation and insulin-dependent diabetes and in rat H4IIE cells. The Vmax. for CPT-I in hepatic mitochondrial outer membranes isolated from starved and diabetic rats increased 2- and 3-fold respectively over fed control values with no change in Km values for substrates. Regulation of mal...