In this paper, the generation of additive red-green-blue (RGB) colors in reflectance mode with near unity amplitude is demonstrated. For purpose, a multilayer structure made metal–insulator–metal–semiconductor–insulator stacks designed to achieve &gt; </mml:mr...

Although disruption of leptin signaling is associated with obesity as well as cardiac lipid accumulation and dysfunction, it has been difficult to separate the direct effects of leptin on the heart from those associated with the effects of leptin on body weight and fat mass. Using Cre-loxP recombinase technology, we developed tamoxifen-inducible, cardiomyocyte-specific leptin receptor-deficient...

Cre is widely used for DNA tailoring and, in combination with recombineering techniques, to modify BAC/PAC sequences for generating transgenic animals. However, mammalian genomes contain recombinase recognition sites (cryptic loxP sites) that can promote illegitimate DNA recombination and damage when cells express the Cre recombinase gene. We have created a new bioinformatic tool, FuzznucCompar...

Sequencing of the 7 kb immC region from four P1-related phages identified a novel DNA recombinase that exhibits many Cre-like characteristics, including recombination in mammalian cells, but which has a distinctly different DNA specificity. DNA sequence comparison to the P1 immC region showed that all phages had related DNA terminase, C1 repressor and DNA recombinase genes. Although these genes...

Let Ω be a bounded open subset of Rn and H(x,p):Ω×Rn→R continuous Hamiltonian that is convex in the second argument. We study asymptotic behavior, as λ→0+, state-constraint Hamilton–Jacobi equation(Sλ){ϕ(λ)uλ(x)+H(x,Duλ(x))⩽0in(1+r(λ))Ω,ϕ(λ)uλ(x)+H(x,Duλ(x))⩾0on(1+r(λ))Ω‾, corresponding additive eigenvalues, or ergodic constant(Eλ){H(x,Dvλ(x))⩽c(λ)in(1+r(λ))Ω,H(x,Dvλ(x))⩾c(λ)on(1+r(λ))Ω‾. Here,...

BACKGROUND The large serine recombinase phiC31 from broad host range Streptomyces temperate phage, catalyzes the site-specific recombination of two recognition sites that differ in sequence, typically known as attachment sites attB and attP. Previously, we characterized the phiC31 catalytic activity and modes of action in the fission yeast Schizosaccharomyces pombe. RESULTS In this work, the ...

Li H, Zhou X, Davis DR, Xu D, Sigmund CD. An androgeninducible proximal tubule-specific Cre recombinase transgenic model. Am J Physiol Renal Physiol 294: F1481–F1486, 2008. First published April 2, 2008; doi:10.1152/ajprenal.00064.2008.—To facilitate the study of renal proximal tubules, we generated a transgenic mouse strain expressing an improved Cre recombinase (iCre) under the control of the...

rats (i, red color), the controlateral part (ii, blue color) and the ipsilateral part (iii, green color). For DIAMOND: λ⁄⁄ ,λ⊥: axial and radial diffusivities, hei: heterogeneity index, Diso: Diffusion isotropic, and fDiso: fraction of Diso. For NODDI: ficvf: intra-cellular volume fraction, fiso: CSF volume fraction and odi: orientation dispersion index. * : statistically significant Characteri...