The adipose tissue-derived protein, adiponectin, has significant anti-inflammatory properties in a variety of disease conditions. Recent evidence that adiponectin and its receptors (AdipoR1 and AdipoR2) are expressed in central nervous system, suggests that it may also have a central modulatory role in pain and inflammation. This study set out to investigate the effects of exogenously applied r...

The peroxisome proliferator-activated receptor(PPAR) is a member of the nuclear receptor superfamily of ligand-dependent transcription factors related to retinoid, steroid, and thyroid hormone receptors. The aim of the present study was to evaluate the role of the PPARreceptor on the development of acute inflammation. To address this question, we used two animal models of acute inflammation (ca...

BACKGROUND Celecoxib exerted analgesic effects (hypoalgesia) reversed by opioid receptor antagonists in a model of inflammatory pain. To analyze this celecoxib-induced hypoalgesia further, we assessed the effects of several disruptors of cytoskeletal components in our model of inflammation. METHODS Hyperalgesia to mechanical stimuli was induced in rat hind paws by intraplantar injection of ca...

The aim of the present study was to evaluate the anti-inflammatory effect of clomipramine in carrageenan- and lipopolysaccharide-induced (LPS-induced) models of inflammation by investigating the changes in serum levels of the pro-inflammatory cytokine TNF-α and the anti-inflammatory cytokines IL-10 and TGF-β after single and repeated administration of the drug. In order to study the effect of s...

The redox behavior cobalt chloride was studied voltammetrically in presence and absence of L- Carrageenan (LK) natural polymer using glassy carbon electrodes in 0.1 M KCl supporting electrode. Scan rates are studied for the redox behaviors for CoCl2 alone or in presence of L- Carrageenan (LK) natural polymer. Stability constants for the interaction of cobalt ions with L - Carageenan (LK) natura...

Abstract Indonesian love beef meatballs. However, meatballs have a high saturated fat content and are expensive. Tilapia fish can replace meatballs’ primary protein source. tilapia has low fillet yield of 20-30%, producing 65-89% waste. The use whole in the production balls increase benefits calcium- phosphorus-rich by-products. Osteoporosis-prone individuals need calcium foods. Notwithstanding...

A novel biohybrid hydrogel nanocomposite made of natural polymer carrageenan and gelatin protein were developed. The silver nanoparticles prepared using the as reduction capping agent. Here, Ag/Carrageenan was combined with glutaraldehyde having a cross-link role in order to create nanocomposite. manufactured composite performances anaylised by UV–visible spectroscopy, Fourier Transform infrare...

Pharmacognosy Research,2023,15,2,258-266.DOI:10.5530/pres.15.2.028Published:February 2023Type:Original Article Authors:Mark Joseph Maranan Desamero, Mikaela Bernadette Andres Rabino, Maria Angelica Rimas Tayao, Mary Jasmin Cabillon Ang, Jussiaea Valente Bariuan, Roxanne Posilero Gapasin, Therese Marie Avena Collantes, Melissa Risos Rondina, Cherry Pambid Fernandez-Colorado, Cleofas Rodriguez Ce...

BACKGROUND Crocin and safranal are the active substances of saffron and have many biological properties. In the present study, we compared the effects of crocin, safranal and diclofenac on local inflammation and its induced pain in rats. METHODS Local inflammation was induced by intraplantar (ipl) injection of carrageenan (100 μl, 2%). Paw thickness was measured before and after carrageenan i...