نتایج جستجو برای: δ9 tetrahydrocannabinol

تعداد نتایج: 3445  

Journal: :Addiction biology 2012
Julie Le Merrer Katia Befort Olivier Gardon Dominique Filliol Emmanuel Darcq Doulaye Dembele Jerome A J Becker Brigitte L Kieffer

Addiction is a chronic brain disorder. Prolonged abstinence from drugs of abuse involves dysphoria, high stress responsiveness and craving. The neurobiology of drug abstinence, however, is poorly understood. We previously identified a unique set of hundred mu-opioid receptor-dependent genes in the extended amygdala, a key site for hedonic and stress processing in the brain. Here we examined the...

2016
Sonia Hernández-Tiedra Gemma Fabriàs David Dávila Íñigo J. Salanueva Josefina Casas L. Ruth Montes Zuriñe Antón Elena García-Taboada María Salazar-Roa Mar Lorente Jesper Nylandsted Jane Armstrong Israel López-Valero Christopher S. McKee Ana Serrano-Puebla Roberto García-López José González-Martínez José L. Abad Kentaro Hanada Patricia Boya Félix Goñi Manuel Guzmán Penny Lovat Marja Jäättelä Alicia Alonso Guillermo Velasco

Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors that dictate the shift between these 2 opposite outcomes remain largely unknown. In this work, we used Δ9-tetrahydrocannabinol (THC, the main active component of marijuana, a compound that triggers autophagy-mediated cancer cell death) and nutrient deprivation (an autophagic ...

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