نتایج جستجو برای: β thalassemia
تعداد نتایج: 195979 فیلتر نتایج به سال:
background: objective: to determine pregnancy outcome of women with β-thalassemia minor. materials and methods: in this retrospective, case-control study in two universities affiliated hospitals in shiraz, all pregnancies occurred between 2006 and 2008 were included. patients were divided in two groups regarding the presence of β-thalassemia minor. patients in case and control groups were m...
BACKGROUND Hemoglobinopathies are the most common inherited diseases in southern China. However, there have been only a few epidemiological studies of hemoglobinopathies in Guangdong province. MATERIALS AND METHODS Peripheral blood samples were collected from 15299 "healthy" unrelated subjects of dominantly ethnic Hakka in the Meizhou region, on which hemoglobin electrophoresis and routine bl...
Sclrostin is a biomarker interrupted in bone resorption process by binding to LRP5 and/or LRP6 family, and prevent Wingless-type signaling (Wnt) which important both development the maintain of mass. Sixty (60) patients with thalassemia major were enrolled from period 2/5/2021 1/9/2021 summer assessment role sclrostin predisposing for osteoporosis β-thalassemia (β-TM). Patients ages (2-40 year)...
The thalassemia syndromes (α- and β-thalassemia) are the most common and frequent disorders associated with ineffective erythropoiesis. Imbalance of α- or β-globin chain production results in impaired red blood cell synthesis, anemia, and more erythroid progenitors in the blood stream. While patients affected by these disorders show definitive altered parameters related to erythropoiesis, the r...
hemoglobin f (hbf, α 2 γ 2 ) is a major contributor to the clinical heterogeneity and ameliorating agent observed in patients with the β-globin disorders including β-thalassemia and sickle cell disease (scd). during fetal life, hbf is the major hemoglobin but is largely substituted by adult hemoglobin (hba, α 2 β 2 ) following a globin expression switch after birth. increased γ-globin expressio...
background: in the previous study, we have shown that the presence of a allele at position -588 in aγ-globin gene was highly frequent and closely associated with fetal hemoglobin elevation among β-thalassemia intermedia patients. therefore, we decided to investigate whether this allele (a allele at -588) could result in an increase in aγ-globin gene expression to ameliorate the severity of the ...
background: efficient induction of fetal hemoglobin (hbf) is considered as an effective therapeutic approach in beta thalassemia. hbf inducer agents can induce the expression of γ-globin gene and produce high levels of hbf via different epigenetic and molecular mechanisms. thalidomide and sodium butyrate are known as hbf inducer drugs. material and methods : cd133 + stem cells were isolated fro...
β-thalassemia is characterized by reduced or absence of β-globin production, resulting in anemia. Current therapies include blood transfusion combined with iron chelation. BM transplantation, although curative, is restricted by the matched donor limitation. Gene therapy, on the other hand, is promising, and its success lies primarily on designing efficient globin vectors that can effectively an...
Background β-thalassemia major is a severe disease with high morbidity. The world prevalence of carriers is around 1.5-7%. The present study aimed to find a reliable formula for detecting β-thalassemia carriers using an extensive database of more than 22,000 samples obtained from a homogeneous population of childbearing age women with 3161 (13.6%) of β-thalassemia carriers and to check previous...
Background: Since many surveys for the prevalence of β thalassemia have been made in area with high prevalence of malaria, it is important to find out whether malaria can modify Hb A2 levels. In present study, analysis of Hb A2 level of patients with malaria and thalassemia has been done and has been compared with control group to conclude that whether Hb A2 level was affected or not. Methodolo...
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